PMID- 22943900
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20231213
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 46
IP  - 6
DP  - 2012 Jun
TI  - [Correlation between interleukin-28B genetic polymorphisms and primary 
      hepatocellular carcinoma].
PG  - 527-32
AB  - OBJECTIVE: To explore the correlation between single nucleotide polymorphisms 
      (SNPs) of interleukin-28B (IL-28B) gene and the susceptibility to primary 
      hepatocellular carcinoma (HCC). METHODS: A total of 300 histologically confirmed 
      HCC cases (from November 2001 to April 2010) and 310 healthy controls with no 
      history of chronic hepatitis B or hepatocellular carcinoma (2009-2010) were 
      selected from a hospital in Guilin and a hospital in Beijing for this 
      case-control study.139 HCC patients in the case group had complete clinical 
      tracking data. All the subjects were Han Chinese, with no age or gender 
      restrictions.2 ml peripheral blood samples were drawn from each subject with 
      informed consent. SNP of rs12972991, rs4803223, rs8099917 and rs12979860 four 
      loci in IL-28B gene were analyzed by matrix-assisted laser desorption/ionization 
      time of flight mass spectrometry (MALDI-TOF). RESULTS: The frequencies of C 
      allele at rs12972991, G allele at rs8099917 and G allele at rs4803223 were 6.7% 
      (40/598), 7.9% (47/598) and 10.0% (59/588) respectively in case group; all higher 
      than the corresponding frequencies in control group, separately 2.9% (18/618), 
      4.1% (25/616) and 3.6% (21/608). The differences were statistically significant 
      (chi2=9.542, 7.858, 20.736, P values all<0.05). The above alleles could increase 
      the risk of HCC, and the OR (95%CI) values were separately 1.67 (1.13-2.46), 1.49 
      (1.08-2.06) and 2.91 (1.79-4.72). The genotype frequencies of AC+CC at 
      rs12972991, GT+GG at rs8099917, GA+GG at rs4803223 were 13.0% (39/299), 14.7% 
      (44/299) and 19.0% (56/296) respectively in case group; while the frequencies 
      were lower in control group, separately 5.8% (18/309), 8.1% (25/308) and 6.6% 
      (20/304). The differences were statistically significant (chi2=9.319, 6.557, 
      20.948, P values all<0.05). These genotypes may increase the risk of HCC, and the 
      adjusted OR (95%CI) values were 2.24 (1.31-3.83), 1.81 (1.14-2.88) and 2.90 
      (1.78-4.70), respectively. The stratified analysis of the clinical data indicated 
      that the frequency of genotype GA+GG at rs4803223 was 50.0% (13/26) in patients 
      of tumor thrombosis in portal vein (TTPV), higher than the frequency of genotype 
      AA (21.1%, 23/109). The difference was statistically significant (chi2=8.965, 
      P=0.003). CONCLUSION: The results suggested that IL-28B gene polymorphisms was 
      correlated to the susceptibility to HCC in Chinese Han ethnic population. Among 
      them, GA + GG genotype at rs4803223 could increase the risk of TTPV in HCC 
      patients.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Hepatobiliary Surgery, Affiliated Hospital, Guilin Medical College, 
      Guilin 541001, China.
FAU - Zhang, Heng-hui
AU  - Zhang HH
FAU - Chen, Yan-hui
AU  - Chen YH
FAU - Xie, Xing-wang
AU  - Xie XW
FAU - Liao, Wei-jia
AU  - Liao WJ
FAU - Qin, Li-ling
AU  - Qin LL
FAU - Sun, Xiu-yun
AU  - Sun XY
FAU - Fei, Ran
AU  - Fei R
FAU - Wang, Xue-yan
AU  - Wang XY
FAU - Wei, Lai
AU  - Wei L
FAU - Chen, Hong-song
AU  - Chen HS
FAU - Mei, Ming-hui
AU  - Mei MH
LA  - chi
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 0 (interferon-lambda, human)
RN  - 0 (Interleukins)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Alleles
MH  - Carcinoma, Hepatocellular/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interferons
MH  - Interleukins/*genetics
MH  - Liver Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2012/09/05 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Jun;46(6):527-32.