PMID- 22944100
OWN - NLM
STAT- MEDLINE
DCOM- 20121212
LR  - 20120904
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 17
IP  - 4
DP  - 2012 Jul
TI  - Homing and engraftment of bone marrow cells derived from different donors in a 
      murine model of sensitization.
PG  - 215-9
LID - 10.1179/102453312X13376952196539 [doi]
AB  - Sensitized recipients are at a high risk of graft rejection in hematopoietic stem 
      cell transplantation. To explore the trace of donor cells, we tried to explore 
      homing and engraftment of bone marrow cells (BMCs) derived from different donors 
      in a murine model of sensitization. Sensitized BALB/c mice were used as 
      transplanted recipients, which received BMCs derived from C57BL/6 or BALB/c 
      donors after lethal irradiation. The homing study showed that the donor cells 
      decreased along with time in recipients of the C57BL/6 donor group, but the donor 
      cells increased along with time in recipients of the BALB/c donor group. For the 
      engraftment assay, all the sensitized recipients transplanted with BMCs derived 
      from C57BL/6 donors died after lethal irradiation. In contrast, all the 
      recipients transplanted with BMCs derived from BALB/c donors got long-term 
      survival. Our results suggest that it is crucial to have human leukocyte antigen 
      identical donors for sensitized recipients during hematopoietic stem cell 
      transplantation.
FAU - Xu, Lu-Hong
AU  - Xu LH
AD  - Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Fang, Jian-Pei
AU  - Fang JP
FAU - Xu, Hong-Gui
AU  - Xu HG
FAU - Weng, Wen-Jun
AU  - Weng WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*immunology
MH  - Bone Marrow Transplantation/*immunology
MH  - Graft Survival/*immunology
MH  - Immunocompromised Host/radiation effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Survival Analysis
MH  - Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2012/09/05 06:00
MHDA- 2012/12/13 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2012/12/13 06:00 [medline]
AID - 10.1179/102453312X13376952196539 [doi]
PST - ppublish
SO  - Hematology. 2012 Jul;17(4):215-9. doi: 10.1179/102453312X13376952196539.