PMID- 22944231
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20120904
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 26
DP  - 2012 Jul 10
TI  - [Characteristics of real-life glucose profiles monitored by continuous glucose 
      monitoring system in persons with normal glucose tolerance].
PG  - 1820-3
AB  - OBJECTIVE: To decipher the characteristics of real-life glucose profiles in 
      normal glucose tolerance (NGT) persons by continuous glucose monitoring system 
      (CGMS). METHODS: Forty NGT subjects confirmed by oral glucose tolerance test 
      (OGTT) completed a 3-day period of glucose monitoring via CGMS. RESULTS: The 
      values of 24 h mean blood glucose (MBG), standard deviation of MBG (SDBG), mean 
      amplitude of glycemic excursions (MAGE), largest amplitude of glycemic excursions 
      (LAGE) and means of daily differences (MODD) were 6.0 +/- 0.7, 0.9 +/- 0.1, 1.9 +/- 
      0.8, 2.9 +/- 1.4 and 1.1 +/- 0.1 mmol/L respectively. Two of them experienced 
      asymptomatic hypoglycemia defined as glucose concentration < 2.8 mmol/L. And 
      72.5% (29/40) subjects reached glucose concentrations > 7.8 mmol/L for 5.2 +/- 4.6 
      hours. In addition to higher glucose concentration (FPG: 5.0 +/- 0.4 vs 4.8 +/- 0.3 
      mmol/L, MBG: 6.4 +/- 0.7 vs 5.7 +/- 0.5 mmol/L), the subjects with glucose 
      concentrations > 7.8 mmol/L showed more dramatic glucose excursion represented by 
      higher SDBG (1.1 +/- 0.3 vs 0.6 +/- 0.2 mmol/L), MAGE (2.3 +/- 1.1 vs 1.1 +/- 0.3 
      mmol/L), LAGE (3.3 +/- 1.2 vs 2.0 +/- 1.0 mmol/L) and MODD (1.2 +/- 0.4 vs 0.9 +/- 0.3 
      mmol/L) versus those with glucose concentrations within 7.8 mmol/L. CONCLUSION: 
      CGMS provides more detailed information of real-life glucose profiles in NGT 
      subjects. And 72.5% NGT subjects in the present study spent a considerable amount 
      of time at pre-diabetic or even diabetic glucose levels characterized by more 
      predominant glucose excursion.
FAU - Xu, Wen
AU  - Xu W
AD  - Department of Endocrinology, Sun Yat-sen University, Guangzhou, China.
FAU - Zhu, Yan-hua
AU  - Zhu YH
FAU - Yan, Jin-hua
AU  - Yan JH
FAU - Yang, Xu-bin
AU  - Yang XB
FAU - Zhang, Guo-chao
AU  - Zhang GC
FAU - Zeng, Long-yi
AU  - Zeng LY
FAU - Weng, Jian-ping
AU  - Weng JP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic/*methods
EDAT- 2012/09/05 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Jul 10;92(26):1820-3.