PMID- 22944544
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20181202
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 31
IP  - 1
DP  - 2013 Jan
TI  - Bradykinin-mediated angioedema: factors prompting ED visits.
PG  - 124-9
LID - S0735-6757(12)00346-4 [pii]
LID - 10.1016/j.ajem.2012.06.021 [doi]
AB  - OBJECTIVE: Bradykinin-mediated angioedema (AE) is characterized by periodic 
      subcutaneous or submucosal swelling, with the absence of urticaria and itching. 
      It affects the face and extremities. Attacks of abdominal pain and obstruction of 
      the upper airways are the hallmarks of disease severity. The aim of this study 
      was to determine the factors prompting patients to turn up at the hospital 
      emergency department (ED) in the event of an attack. METHODS: This was a 
      retrospective review of attacks experienced by all patients with 
      bradykinin-mediated AE (hereditary, acquired, or drug-induced) who visited our ED 
      between January 2002 and March 2011. Characteristics of attacks prompting ED 
      visits and attacks when patients stayed at home were compared using logistic 
      regression with generalized estimating equations to take into account the 
      correlation between multiple attacks from the same patient. RESULTS: A total of 
      55 patients were included, of whom 39 had hereditary AE; 13, drug-induced AE; and 
      3, acquired C1 inhibitor deficiency. The median follow-up was 32 months 
      (interquartile range, 10-99 months). The attack was severe in 324 (58%) of 559 
      cases. Thirty-two patients (58%) visited the ED for a total of 75 attacks. First 
      attack and laryngeal edema were significantly associated with more frequent ED 
      visits (odds ratio, 5.28 [95% confidence interval, 2.42-11.5] and 4.83 
      [1.54-15.5], respectively]. C1 inhibitor concentrate and icatibant treatment was 
      significantly more often administered in the ED than at home (odds ratio, 4.9 
      [2.43-9.88] and 8.25 [2.4-28.3], respectively). CONCLUSIONS: First attack of 
      bradykinin AE and swelling of the larynx were significantly associated with 
      visits to the ED.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Javaud, Nicolas
AU  - Javaud N
AD  - Service des Urgences, Centre de Reference associe sur les angioedemes a kinines, 
      Assistance Publique-Hopitaux de Paris, Hopital Jean Verdier, Groupe hospitalier 
      Hopitaux Universitaires Paris Seine-Saint-Denis, Universite Paris 13, Bondy, 
      France. nicolas.javaud@jvr.aphp.fr
FAU - Karami, Ahmed
AU  - Karami A
FAU - Stirnemann, Jerome
AU  - Stirnemann J
FAU - Pilot, Florence
AU  - Pilot F
FAU - Branellec, Albanne
AU  - Branellec A
FAU - Boubaya, Marouane
AU  - Boubaya M
FAU - Chassaignon, Cecile
AU  - Chassaignon C
FAU - Adnet, Frederic
AU  - Adnet F
FAU - Fain, Olivier
AU  - Fain O
LA  - eng
PT  - Journal Article
DEP - 20120831
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Adult
MH  - Angioedema/*diagnosis/*therapy
MH  - Bradykinin/*physiology
MH  - Emergency Service, Hospital/*statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2012/09/05 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/06/22 00:00 [revised]
PHST- 2012/06/23 00:00 [accepted]
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - S0735-6757(12)00346-4 [pii]
AID - 10.1016/j.ajem.2012.06.021 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2013 Jan;31(1):124-9. doi: 10.1016/j.ajem.2012.06.021. Epub 2012 
      Aug 31.