PMID- 22945215
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20120904
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 24 Suppl 1
DP  - 2012 Sep
TI  - The brain derived neurotrophic factor and influences of stress in depression.
PG  - S169-71
AB  - Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family 
      and is widely expressed throughout the central nervous system (CNS). BDNF is 
      involved in proliferation, differentiation, survival and death of neuronal and 
      non-neuronal cells in the developing and adult CNS. The BDNF hypothesis of 
      depression postulates that a reduction in BDNF is directly involved in the 
      pathophysiology of depression, whilst anti-depressant mediated restoration of 
      BDNF is responsible for the alleviation of the depressive state. This hypothesis 
      is drawn from several studies implicating BDNF in depression and has received 
      considerable support, which will be reviewed in this paper. This review will also 
      discuss the implications of the functional Val66Met polymorphism of the gene 
      encoding BDNF, which may reduce BDNF expression particularly when exposed to 
      stress and thus may play a critical role in the pathogenesis of depression.
FAU - Kimpton, Jessica
AU  - Kimpton J
AD  - The University of Manchester, Oxford Road, Manchester M13 9PL, UK. 
      Jessica.kimpton@doctors.org.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Brain/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depressive Disorder, Major/drug therapy/*physiopathology
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/drug effects/physiopathology
MH  - *Life Change Events
MH  - Limbic System/physiopathology
MH  - Pituitary-Adrenal System/drug effects/physiopathology
MH  - Risk Factors
EDAT- 2012/11/28 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2012 Sep;24 Suppl 1:S169-71.