PMID- 22947590
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20211021
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 38
DP  - 2012 Sep 4
TI  - Cardiac troponin I levels and its relation to echocardiographic findings in 
      infants of diabetic mothers.
PG  - 39
LID - 10.1186/1824-7288-38-39 [doi]
AB  - BACKGROUND: Cardiomyopathy is noted in up to 40% of infants of diabetic mothers, 
      and the exact mechanisms responsible for it are unknown. The aim of this study 
      was to compare between infants of diabetic mothers (IDM) and infants of non- 
      diabetic mothers (INDM) as regards cardiac troponin I (cTnI) levels (as a marker 
      of cardiac dysfunction) and to examine the relationship between this marker and 
      neonatal echocardiographic changes (cardiac structure and function). METHODS: A 
      prospective, comparative study included eighty full term neonates during the 
      first three days of life, during the period from April 2008 to June 2011. They 
      were divided into 2 groups, group I: included 40 infants of diabetic mothers 
      (IDMs)and group II: included 40 infants of non diabetic healthy mothers as a 
      control group. RESULTS: 37.5% of the IDMs were large for gestational age and 
      demonstrated a significantly lower blood glucose level than the control group 
      (34.6 +/- 11.3mg/dl Vs 77.2 +/- 19.8 mg/dl respectively) , respiratory distress and 
      cyanosis were the presenting signs in 67.5% of IDMs. Cardiac TnI on the second 
      day of life increased significantly in infants of diabetic mothers in comparison 
      to INDM (p < 0.006) . IDMs had a significant increase in left atrial thickness ( 
      11.5 +/- 1.8mm in IDM Vs 10.5 +/- 0.9mm in INDM P < 0.002*) and a significant 
      increase in septal thickness (5.0 +/- 1.2mm in IDM Vs 4.0 +/- 0.5mm in INDM P < 
      0.001*). CTnI correlated positively with interventricular septum thickness 
      (P-value = 0.002*). Cardiac TnI was significantly increased in IDMs with 
      respiratory distress (P -value < 0.05). CONCLUSIONS: This study demonstrated a 
      highly significant positive correlation between cTnI level on the second day of 
      life and the left ventricular end diastolic diameter (LVED) and interventricular 
      septum diameter (IVSD). Cardiac troponin I (cTnI) is a useful biochemical marker 
      for monitoring myocardial injury in infants of diabetic mothers. An elevated cTnI 
      concentration in infants of diabetic mothers with respiratory distress was a good 
      predictor for hypertrophic cardiomyopathy and/or left ventricular dysfunction.
FAU - Korraa, Afaf
AU  - Korraa A
AD  - Pediatrics department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, 
      Egypt. khaled_hg@hotmail.com
FAU - Ezzat, Mohamed Hesham
AU  - Ezzat MH
FAU - Bastawy, Mahmoud
AU  - Bastawy M
FAU - Aly, Hassan
AU  - Aly H
FAU - El-Mazary, Abdel-Azeem
AU  - El-Mazary AA
FAU - Abd El-Aziz, Lobna
AU  - Abd El-Aziz L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120904
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
SB  - IM
MH  - Biomarkers/blood
MH  - Cardiomyopathies/*blood/*diagnostic imaging
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - *Diabetes, Gestational
MH  - *Echocardiography
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Mothers
MH  - Pregnancy
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Troponin I/*blood
PMC - PMC3523030
EDAT- 2012/09/06 06:00
MHDA- 2013/03/13 06:00
PMCR- 2012/09/04
CRDT- 2012/09/06 06:00
PHST- 2012/01/28 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PHST- 2012/09/04 00:00 [pmc-release]
AID - 1824-7288-38-39 [pii]
AID - 10.1186/1824-7288-38-39 [doi]
PST - epublish
SO  - Ital J Pediatr. 2012 Sep 4;38:39. doi: 10.1186/1824-7288-38-39.