PMID- 22948508
OWN - NLM
STAT- MEDLINE
DCOM- 20130924
LR  - 20180816
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 93
IP  - 2
DP  - 2013 Mar 27
TI  - Association of nerve growth factor, chemokine (C-C motif) ligands and 
      immunoglobulin E with pruritus in cutaneous T-cell lymphoma.
PG  - 144-9
LID - 10.2340/00015555-1428 [doi]
AB  - Many patients with cutaneous T-cell lymphoma (CTCL) experience severe pruritus. 
      This study evaluated serum levels of nerve growth factor (NGF) and brain-derived 
      neurotrophic factor (BDNF) in patients with CTCL. Although serum NGF and BDNF 
      levels in patients with CTCL were not significantly higher than in healthy 
      controls, serum NGF levels in patients with Sezary syndrome were higher than in 
      those with mycosis fungoides and in healthy controls. Enhanced NGF expression by 
      keratinocytes and increased dermal nerve fibres were detected in lesional skin of 
      subjects with Sezary syndrome. Correlations between pruritus in CTCL and serum 
      levels of NGF, BDNF, chemokine (C-C motif) ligand 1 (CCL1), CCL17, CCL26, CCL27, 
      lactate dehydrogenase (LDH), IgE, and soluble interleukin-2 receptor were 
      analysed. Serum CCL1, CCL26, LDH, and IgE levels correlated with pruritus in 
      patients with CTCL. NGF may be associated with increased dermal nerve fibres and 
      pruritus in Sezary syndrome, and CCL1, CCL26, and IgE may be associated with 
      pruritus in CTCL.
FAU - Suga, Hiraku
AU  - Suga H
AD  - Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 
      Tokyo, Japan.
FAU - Sugaya, Makoto
AU  - Sugaya M
FAU - Miyagaki, Tomomitsu
AU  - Miyagaki T
FAU - Ohmatsu, Hanako
AU  - Ohmatsu H
FAU - Fujita, Hideki
AU  - Fujita H
FAU - Kagami, Shinji
AU  - Kagami S
FAU - Asano, Yoshihide
AU  - Asano Y
FAU - Tada, Yayoi
AU  - Tada Y
FAU - Kadono, Takafumi
AU  - Kadono T
FAU - Sato, Shinichi
AU  - Sato S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (CCL1 protein, human)
RN  - 0 (CCL26 protein, human)
RN  - 0 (Chemokine CCL1)
RN  - 0 (Chemokine CCL26)
RN  - 0 (Chemokines, CC)
RN  - 0 (NGF protein, human)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Case-Control Studies
MH  - Chemokine CCL1/*blood
MH  - Chemokine CCL26
MH  - Chemokines, CC/*blood
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Lymphoma, T-Cell, Cutaneous/blood/complications/*immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Mycosis Fungoides/blood/immunology
MH  - Nerve Growth Factor/*blood
MH  - Pruritus/*immunology/pathology
MH  - Sezary Syndrome/blood/immunology
MH  - Skin/*innervation/pathology
MH  - Skin Neoplasms/blood/complications/*immunology/pathology
EDAT- 2012/09/06 06:00
MHDA- 2013/09/26 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
AID - 10.2340/00015555-1428 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2013 Mar 27;93(2):144-9. doi: 10.2340/00015555-1428.