PMID- 22949741
OWN - NLM
STAT- MEDLINE
DCOM- 20141030
LR  - 20131216
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Linking)
VI  - 20
IP  - 1
DP  - 2014 Jan
TI  - Evaluating unfractionated heparin fixed dosing protocol and establishing an 
      institutional therapeutic range for UFH in hospital setting in Jordan.
PG  - 73-7
LID - 10.1177/1076029612458722 [doi]
AB  - This study was conducted to evaluate current unfractionated heparin (UFH) dosing 
      regimen and establish an institutional therapeutic range for UFH in a public 
      hospital in Jordan. In the first part, medical records of 241 patients who 
      received UFH were reviewed retrospectively. In the second part, blood samples 
      were withdrawn from 60 patients on UFH, and activated partial thromboplastin time 
      and anti-Xa assay were measured. Most activated partial thromboplastin time 
      readings were not therapeutic (91.4%) and recurrence of thrombosis was reported 
      in 35.3% of patients. In the second part, therapeutic activated partial 
      thromboplastin time range corresponding to the UFH concentration of 0.3 to 0.7 
      anti-factor Xa unit/mL was 56 to 95 seconds, which corresponds to an activated 
      partial thromboplastin time range of 1.5 of 2.8 times the mean control value. The 
      traditional activated partial thromboplastin time range ratio of 1.5 to 2.5 times 
      the control value can result in subtherapeutic UFH levels.
FAU - Tahaineh, Linda
AU  - Tahaineh L
AD  - 1Department of Clinical Pharmacy, Jordan University of Science & Technology 
      (JUST), Irbid, Jordan.
FAU - Albsoul-Younes, Abla
AU  - Albsoul-Younes A
FAU - Iflaifel, Mais
AU  - Iflaifel M
FAU - Shehabi, Iman
AU  - Shehabi I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120903
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*administration & dosage
MH  - Data Collection
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Heparin/*administration & dosage
MH  - Humans
MH  - Jordan
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Jordan
OT  - anticoagulants
OT  - dosing regimen
OT  - institutional therapeutic range
OT  - unfractionated heparin
EDAT- 2012/09/06 06:00
MHDA- 2014/10/31 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2014/10/31 06:00 [medline]
AID - 1076029612458722 [pii]
AID - 10.1177/1076029612458722 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2014 Jan;20(1):73-7. doi: 10.1177/1076029612458722. Epub 
      2012 Sep 3.