PMID- 2294993
OWN - NLM
STAT- MEDLINE
DCOM- 19900209
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 75
IP  - 1
DP  - 1990 Jan 1
TI  - Pure red cell aplasia of long duration complicating major ABO-incompatible bone 
      marrow transplantation.
PG  - 290-5
AB  - In 3 of 15 consecutive patients receiving a human leukocyte antigen 
      (HLA)-identical but major ABO incompatible bone marrow transplant (BMT), pure red 
      cell aplasia (PRA) lasting 5 to 8 months was observed. Titers of the incompatible 
      anti-A agglutinin before infusion of the red blood cell (RBC)-depleted BMT was 
      very high in one, and in the usual range in two patients. Decrease of agglutinin 
      titers during the first 4 weeks after BMT were comparable between PRA patients 
      and those of ABO-incompatible BMT recipients with timely RBC recovery. However, 
      in PRA patients, agglutinin titers rose again and remained elevated for 19 to 28 
      weeks. RBC engraftment and reticulocyte recovery ultimately occurred 
      spontaneously and coincided with the decrease of agglutinin titers below 16. 
      These observations indicate that PRA is antibody-dependent in this setting. 
      Furthermore, it is conceivable that cyclosporine facilitates recipient-derived 
      antibody synthesis after major ABO-incompatible BMT.
FAU - Gmur, J P
AU  - Gmur JP
AD  - Department of Internal Medicine, University Hospital, Zurich, Switzerland.
FAU - Burger, J
AU  - Burger J
FAU - Schaffner, A
AU  - Schaffner A
FAU - Neftel, K
AU  - Neftel K
FAU - Oelz, O
AU  - Oelz O
FAU - Frey, D
AU  - Frey D
FAU - Metaxas, M
AU  - Metaxas M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Isoantibodies)
SB  - IM
CIN - Blood. 1991 Feb 15;77(4):906. PMID: 1899624
MH  - ABO Blood-Group System
MH  - Blood Group Incompatibility/*complications
MH  - *Bone Marrow Transplantation
MH  - *Erythropoiesis
MH  - Graft vs Host Disease/prevention & control
MH  - Humans
MH  - Isoantibodies/analysis
MH  - Time Factors
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - S0006-4971(20)85851-0 [pii]
PST - ppublish
SO  - Blood. 1990 Jan 1;75(1):290-5.