PMID- 22949982
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Print)
IS  - 2005-6419 (Linking)
VI  - 63
IP  - 2
DP  - 2012 Aug
TI  - Effect of a single bolus of methylene blue prophylaxis on vasopressor and 
      transfusion requirement in infective endocarditis patients undergoing cardiac 
      surgery.
PG  - 142-8
LID - 10.4097/kjae.2012.63.2.142 [doi]
AB  - BACKGROUND: The accentuated nitric oxide (NO) release that is induced by the 
      systemic inflammatory response associated with infective endocarditis (IE) and 
      cardiopulmonary bypass (CPB) may result in catecholamine refractory hypotension 
      (vasoplegia) and increased transfusion requirement due to platelet inhibition. 
      Methylene blue (MB) is an inhibitory drug of inducible NO. We aimed to evaluate 
      the effect of prophylactic MB administration before CPB on vasopressor and 
      transfusion requirements in patients with IE undergoing valvular heart surgery 
      (VHS). METHODS: Forty-two adult patients were randomly assigned to receive 2 
      mg/kg of MB (MB group, n = 21) or saline (control group, n = 21) for 20 min 
      before the initiation of CPB. The primary end points were comparisons of 
      vasopressor requirements serially assessed after weaning from CPB and hemodynamic 
      parameters serially recorded before and after CPB. The secondary endpoint was the 
      comparison of transfusion requirements. RESULTS: Two patients in the control 
      group received MB after weaning from CPB due to norepinephrine and vasopressin 
      refractory vasoplegia and were thus excluded. There were no significant 
      differences in vasopressor requirements and hemodynamic parameters between the 
      two groups. The mean number of units of packed erythrocytes transfused per 
      transfused patient was significantly less in the MB group. The numbers of 
      patients transfused with fresh frozen plasma and platelet concentrates were less 
      in the MB group. CONCLUSIONS: In IE patients undergoing VHS, prophylactic MB 
      administration before CPB did not confer significant benefits in terms of 
      vasopressor requirements and hemodynamic parameters, but it was associated with a 
      significant reduction in transfusion requirement.
FAU - Cho, Jin Sun
AU  - Cho JS
AD  - Department of Anesthesiology and Pain Medicine, Yonsei University College of 
      Medicine, Seoul, Korea.
FAU - Song, Jong Wook
AU  - Song JW
FAU - Na, Sungwon
AU  - Na S
FAU - Moon, Joo-Hwa
AU  - Moon JH
FAU - Kwak, Young Lan
AU  - Kwak YL
LA  - eng
PT  - Journal Article
DEP - 20120814
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC3427807
OTO - NOTNLM
OT  - Cardiopulmonary bypass
OT  - Infective endocarditis
OT  - Methylene blue
OT  - Vasoplegia
EDAT- 2012/09/06 06:00
MHDA- 2012/09/06 06:01
PMCR- 2012/08/01
CRDT- 2012/09/06 06:00
PHST- 2011/10/28 00:00 [received]
PHST- 2012/02/16 00:00 [revised]
PHST- 2012/02/17 00:00 [accepted]
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2012/09/06 06:01 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - 10.4097/kjae.2012.63.2.142 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2012 Aug;63(2):142-8. doi: 10.4097/kjae.2012.63.2.142. Epub 
      2012 Aug 14.