PMID- 22950048
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120906
LR  - 20211021
IS  - 2162-3279 (Electronic)
IS  - 2162-3279 (Print)
VI  - 2
IP  - 4
DP  - 2012 Jul
TI  - A promising randomized trial of a new therapy for obsessive-compulsive disorder.
PG  - 443-54
LID - 10.1002/brb3.67 [doi]
AB  - Pharmacotherapy and cognitive-behavioral therapy (CBT) are currently the most 
      effective interventions for treating obsessive-compulsive disorder (OCD). These 
      treatments, however, are time consuming and in some cases the patients do not 
      show significant improvement. In all, 30%-60% of OCD patients do not respond 
      adequately to pharmacotherapy and 20%-40% of OCD patients who complete CBT do not 
      improve significantly, suggesting a more efficacious approach is needed. The 
      objectives of this study are to demonstrate an efficacious pharmacotherapy plus 
      psychotherapy, named cognitive-coping therapy (CCT), for OCD and to investigate 
      the efficacy of this approach in a larger sample size. Therefore, a total of 108 
      patients with OCD were randomly allocated into three groups: pharmacotherapy (N = 
      38), pharmacotherapy plus CBT (PCBT, N = 34), and pharmacotherapy plus CCT (PCCT, 
      N = 36). The severity of symptoms and the patients' functioning were assessed 
      pretreatment and after 7, 14, 21 days, and 1-, 3-, 6-, and 12-month treatment 
      using the Yale-Brown Obsessive Compulsive Scale and Global Assessment of 
      Functioning (GAF). Compared with the pharmacotherapy and PCBT groups, the 
      severity of OCD symptoms was significantly reduced (P < 0.001), the rates of 
      response (100%) and remission (85.0%) were significantly higher (P < 0.001), and 
      relapse rate was lower (P = 0.017) in PCCT group during the 1-year follow-up. In 
      addition, the GAF score was significantly higher in the PCCT group than in the 
      other two groups (P < 0.001). Our preliminary data suggest that PCCT is a more 
      efficacious psychotherapy for OCD patients than pharmacotherapy or PCBT.
FAU - Hu, Xian-Zhang
AU  - Hu XZ
FAU - Wen, You-Sheng
AU  - Wen YS
FAU - Ma, Jian-Dong
AU  - Ma JD
FAU - Han, Dong-Ming
AU  - Han DM
FAU - Li, Yu-Xia
AU  - Li YX
FAU - Wang, Shu-Fan
AU  - Wang SF
LA  - eng
PT  - Journal Article
DEP - 20120626
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
PMC - PMC3432967
OTO - NOTNLM
OT  - Cognitive-behavioral therapy
OT  - OCD
OT  - cognitive-coping therapy
OT  - remission
OT  - response
EDAT- 2012/09/06 06:00
MHDA- 2012/09/06 06:01
PMCR- 2012/07/01
CRDT- 2012/09/06 06:00
PHST- 2011/10/29 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/04/21 00:00 [accepted]
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2012/09/06 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 10.1002/brb3.67 [doi]
PST - ppublish
SO  - Brain Behav. 2012 Jul;2(4):443-54. doi: 10.1002/brb3.67. Epub 2012 Jun 26.