PMID- 2295053 OWN - NLM STAT- MEDLINE DCOM- 19900213 LR - 20190619 IS - 0008-543X (Print) IS - 0008-543X (Linking) VI - 65 IP - 2 DP - 1990 Jan 15 TI - Hairy cell leukemia in two siblings. A human leukocyte antigen-linked disease? PG - 319-21 AB - Shared haplotypes have been documented in three of the four previously reported families with familial hairy cell leukemia (HCL). Human leukocyte antigen (HLA) typing was done on a four-member sibship in which two siblings had hairy cell leukemia. The two affected siblings share the haplotype A2; Bw6, Bw62(15); Cw1; DR4, DRw53; DQw3. No one HLA antigen or haplotype is common among the five families reported at this time. These limited data suggest HCL is not associated with a specific HLA antigen. HLA typing of a larger collection of cases of familial HCL may help better define what role, if any, inheritance plays in the occurrence of this rare disorder among numerous first degree relatives. FAU - Ward, F T AU - Ward FT AD - Department of Pathology, Walter Reed Army Medical Center, Washington, DC 20037-5001. FAU - Baker, J AU - Baker J FAU - Krishnan, J AU - Krishnan J FAU - Dow, N AU - Dow N FAU - Kjobech, C H AU - Kjobech CH LA - eng PT - Case Reports PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - Cancer JT - Cancer JID - 0374236 RN - 0 (HLA Antigens) SB - IM MH - Aged MH - HLA Antigens/*genetics MH - Haplotypes/genetics MH - Humans MH - Leukemia, Hairy Cell/*genetics MH - Male MH - Middle Aged EDAT- 1990/01/15 00:00 MHDA- 1990/01/15 00:01 CRDT- 1990/01/15 00:00 PHST- 1990/01/15 00:00 [pubmed] PHST- 1990/01/15 00:01 [medline] PHST- 1990/01/15 00:00 [entrez] AID - 10.1002/1097-0142(19900115)65:2<319::aid-cncr2820650222>3.0.co;2-x [doi] PST - ppublish SO - Cancer. 1990 Jan 15;65(2):319-21. doi: 10.1002/1097-0142(19900115)65:2<319::aid-cncr2820650222>3.0.co;2-x.