PMID- 22950963
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20130228
IS  - 1448-5990 (Electronic)
IS  - 1031-3613 (Linking)
VI  - 25
IP  - 2
DP  - 2013
TI  - The role of hypoxia-induced genes in ovarian angiogenesis.
PG  - 343-50
LID - 10.1071/RD12139 [doi]
AB  - The hypoxic microenvironment that occurs in fast-growing tissue such as the 
      corpus luteum (CL) is a major contributor to its ability to survive via the 
      induction of an intricate vascular network. Cellular responses to hypoxia are 
      mediated by hypoxia-inducible factor-1 (HIF-1), an oxygen-regulated 
      transcriptional activator. HIF-1, a heterodimer consisting of a 
      constitutively-expressed beta subunit and an oxygen-regulated alpha subunit, binds to 
      the hypoxia responsive element (HRE) present in the promoter regions of 
      responsive genes. This review summarises evidence for the involvement of hypoxia 
      and HIF-1alpha in CL development and function. Special emphasis is given to 
      hypoxia-induced, luteal cell-specific expression of multiple genes (vascular 
      endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF-2), 
      prokineticin receptor 2 (PK-R2), stanniocalcin 1 (STC-1) and endothelin 2 (EDN-2) 
      that participate in the angiogenic process during CL formation.
FAU - Meidan, Rina
AU  - Meidan R
AD  - Department of Animal Sciences, The Hebrew University of Jerusalem, The Robert H. 
      Smith Faculty of Agriculture, Food and Environment, Rehovot 76100, Israel. 
      rina.meidan@huji.ac.il
FAU - Klipper, Eyal
AU  - Klipper E
FAU - Zalman, Yulia
AU  - Zalman Y
FAU - Yalu, Ronit
AU  - Yalu R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Reprod Fertil Dev
JT  - Reproduction, fertility, and development
JID - 8907465
RN  - 0 (Endothelin-2)
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Glycoproteins)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Neuropeptides)
RN  - 0 (PROK2 protein, human)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 76687-96-2 (teleocalcin)
SB  - IM
MH  - Cell Hypoxia/*physiology
MH  - Corpus Luteum/embryology/*metabolism
MH  - Endothelin-2/metabolism
MH  - Female
MH  - Fibroblast Growth Factor 2/metabolism
MH  - Gastrointestinal Hormones/metabolism
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Glycoproteins/metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*metabolism
MH  - Models, Biological
MH  - Neovascularization, Physiologic/genetics/*physiology
MH  - Neuropeptides/metabolism
MH  - Ovary/*blood supply/*embryology
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2012/09/07 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - RD12139 [pii]
AID - 10.1071/RD12139 [doi]
PST - ppublish
SO  - Reprod Fertil Dev. 2013;25(2):343-50. doi: 10.1071/RD12139.