PMID- 22951260
OWN - NLM
STAT- MEDLINE
DCOM- 20130816
LR  - 20160301
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 89
IP  - 5-6
DP  - 2012 Dec 1
TI  - Alterations in grooming activity and syntax in heterozygous SERT and BDNF 
      knockout mice: the utility of behavior-recognition tools to characterize mutant 
      mouse phenotypes.
PG  - 168-76
LID - S0361-9230(12)00185-2 [pii]
LID - 10.1016/j.brainresbull.2012.08.004 [doi]
AB  - Serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) are key 
      modulators of molecular signaling, cognition and behavior. Although SERT and BDNF 
      mutant mouse phenotypes have been extensively characterized, little is known 
      about their self-grooming behavior. Grooming represents an important behavioral 
      domain sensitive to environmental stimuli and is increasingly used as a model for 
      repetitive behavioral syndromes, such as autism and attention 
      deficit/hyperactivity disorder. The present study used heterozygous ((+/-)) SERT 
      and BDNF male mutant mice on a C57BL/6J background and assessed their spontaneous 
      self-grooming behavior applying both manual and automated techniques. Overall, 
      SERT(+/-) mice displayed a general increase in grooming behavior, as indicated by 
      more grooming bouts and more transitions between specific grooming stages. 
      SERT(+/-) mice also aborted more grooming bouts, but showed generally unaltered 
      activity levels in the observation chamber. In contrast, BDNF(+/-) mice displayed 
      a global reduction in grooming activity, with fewer bouts and transitions between 
      specific grooming stages, altered grooming syntax, as well as hypolocomotion and 
      increased turning behavior. Finally, grooming data collected by manual and 
      automated methods (HomeCageScan) significantly correlated in our experiments, 
      confirming the utility of automated high-throughput quantification of grooming 
      behaviors in various genetic mouse models with increased or decreased grooming 
      phenotypes. Taken together, these findings indicate that mouse self-grooming 
      behavior is a reliable behavioral biomarker of genetic deficits in SERT and BDNF 
      pathways, and can be reliably measured using automated behavior-recognition 
      technology.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kyzar, Evan J
AU  - Kyzar EJ
AD  - Department of Pharmacology and Neuroscience Program, Tulane University Medical 
      School, New Orleans, LA 70112, USA.
FAU - Pham, Mimi
AU  - Pham M
FAU - Roth, Andrew
AU  - Roth A
FAU - Cachat, Jonathan
AU  - Cachat J
FAU - Green, Jeremy
AU  - Green J
FAU - Gaikwad, Siddharth
AU  - Gaikwad S
FAU - Kalueff, Allan V
AU  - Kalueff AV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120819
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a4 protein, mouse)
SB  - IM
EIN - Brain Res Bull. 2015 Oct;119(Pt A):101-3
MH  - Animals
MH  - Automation, Laboratory/methods
MH  - Behavior, Animal/physiology
MH  - Brain-Derived Neurotrophic Factor/*deficiency/genetics
MH  - Grooming/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Mutant Strains
MH  - *Phenotype
MH  - Serotonin Plasma Membrane Transport Proteins/*deficiency/genetics
EDAT- 2012/09/07 06:00
MHDA- 2013/08/21 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/05/24 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/08/08 00:00 [accepted]
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S0361-9230(12)00185-2 [pii]
AID - 10.1016/j.brainresbull.2012.08.004 [doi]
PST - ppublish
SO  - Brain Res Bull. 2012 Dec 1;89(5-6):168-76. doi: 
      10.1016/j.brainresbull.2012.08.004. Epub 2012 Aug 19.