PMID- 22951781
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20161125
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 112
IP  - 5
DP  - 2012
TI  - [The effect of neurotrophic treatment on the activation of reparative processes 
      in patients with acute traumatic brain injury].
PG  - 46-9
AB  - The complex study of cognitive and emotional status, levels of serum serotonin 
      and brain-derived neurotrophic factor (BDNF) were performed in 72 patients with 
      acute traumatic brain injury, with a special focus on middle brain injuries 
      (MBI), treated with Cerebrolysin. The neurological and cognitive impairment, mild 
      state anxiety and depression and increased levels of humoral serotonin, which 
      depends on the severity of the injury, were identified in patients with MBI 
      before treatment. After the treatment, there were the decrease in the severity of 
      neurological symptoms and a significant positive dynamics on the FAB scale as 
      well as the increase in blood BDNF and serotonin levels. It has been concluded 
      that using cerebrolysin in complex treatment of acute MBI promotes activation of 
      neurotrophic processes and improves outcomes of closed craniocerebral injury.
FAU - Selianina, N V
AU  - Selianina NV
FAU - Karakulova, Iu V
AU  - Karakulova IuV
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - 0 (Amino Acids)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 37KZM6S21G (cerebrolysin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amino Acids/*therapeutic use
MH  - Anxiety/diagnosis/psychology
MH  - Brain Injuries/*blood/*drug therapy/psychology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition/drug effects
MH  - Cognition Disorders/diagnosis/psychology
MH  - Depression/diagnosis/psychology
MH  - Emotions/drug effects
MH  - Female
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroprotective Agents/*therapeutic use
MH  - Serotonin/*blood
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/09/07 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(5):46-9.