PMID- 22952119
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20130109
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 10
DP  - 2012 Sep 28
TI  - Segmentational analysis of retinal thickness after vitrectomy in diabetic macular 
      edema.
PG  - 6668-74
AB  - PURPOSE: To measure the inner and outer retinal thicknesses on spectral-domain 
      optical coherence tomography (SD-OCT) and evaluate their association with logMAR 
      after vitrectomy for diabetic macular edema (DME). METHODS: In this retrospective 
      case series, there were 55 consecutive eyes with DME for which vitrectomy was 
      performed. The total retinal thickness, the inner thickness (from the innermost 
      of the retina to the inner nuclear layer), and the outer thickness (from the 
      outer plexiform layer to the retinal pigment epithelium) in the parafoveal 
      subfields were measured manually, and the association with logMAR was evaluated. 
      RESULTS: The total retinal thicknesses in the central, nasal, and inferior 
      subfields were significantly (r = 0.37, P = 0.005; r = 0.29, P = 0.032; r = 0.33, 
      P = 0.015, respectively) associated with the baseline logMAR; no subfield 
      thickness was correlated with the logMAR at the final visit. However, 
      segmentational analysis showed that the outer retinal thickness of the temporal 
      subfield was associated with disruption of the junction between the inner and 
      outer segments at the fovea (P = 0.021 and P = 0.005) and negatively correlated 
      with the logMAR (r = -0.37, P = 0.006 and r = -0.28, P = 0.042) at the 6-month 
      and final visit. The inner thickness of the nasal subfield did not change after 
      vitrectomy compared with the other subfields and the outer thickness of all 
      subfields in the parafoveal area; the baseline nasal total thickness was 
      correlated most significantly with the logMAR (r = 0.40, P = 0.002 and r = 0.37, 
      P = 0.006) at the 6-month and final visits. CONCLUSIONS: Segmentational analysis 
      provided useful information for considering the prognosis and pathogenesis after 
      vitrectomy for DME.
FAU - Murakami, Tomoaki
AU  - Murakami T
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan. mutomo@kuhp.kyoto-u.ac.jp
FAU - Nishijima, Kazuaki
AU  - Nishijima K
FAU - Akagi, Tadamichi
AU  - Akagi T
FAU - Uji, Akihito
AU  - Uji A
FAU - Horii, Takahiro
AU  - Horii T
FAU - Ueda-Arakawa, Naoko
AU  - Ueda-Arakawa N
FAU - Muraoka, Yuki
AU  - Muraoka Y
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120928
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Diabetic Retinopathy/*complications/pathology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertrophy
MH  - Macular Edema/etiology/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prognosis
MH  - Retina/*pathology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Tomography, Optical Coherence
MH  - *Vitrectomy
EDAT- 2012/09/07 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - iovs.12-9934 [pii]
AID - 10.1167/iovs.12-9934 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6668-74. doi: 10.1167/iovs.12-9934.