PMID- 22956574
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20230112
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 14
IP  - 12
DP  - 2012 Dec
TI  - Chronic kidney disease and cardiac remodelling in patients with mild heart 
      failure: results from the REsynchronization reVErses Remodeling in Systolic Left 
      vEntricular Dysfunction (REVERSE) study.
PG  - 1420-8
LID - 10.1093/eurjhf/hfs135 [doi]
AB  - AIMS: Chronic kidney disease (CKD) is a risk factor for left ventricular 
      hypertrophy (LVH) and heart failure. We evaluated the effect of CKD on left 
      ventricular (LV) remodelling among patients with mild heart failure. METHODS AND 
      RESULTS: REVERSE was a randomized, controlled trial evaluating cardiac 
      resynchronization therapy (CRT) in patients with New York Heart Association 
      (NYHA) class I/II heart failure. CKD was defined as an estimated glomerular 
      filtration rate (eGFR) <60 mL/min/1.73 m(2). We compared changes in LV function 
      and size over the course of 12 months by CKD status using linear mixed models 
      adjusted for demographics, co-morbidities, medications, cardiomyopathy aetiology, 
      and CRT status. Finally, we evaluated the effect of CKD on cardiac remodelling 
      among patients randomized to CRT on or off. CKD was associated with worsening LV 
      function and dilation compared with the non-CKD group adjusted, 12-month beta 
      coefficients for the CKD group compared with the non-CKD referent group: LV 
      ejection fraction (%) [-1.80, 95% confidence interval (CI) -3.36 to -0.24], LV 
      end-systolic volume (mL) (14.16, 95% CI 3.96-24.36), LV end-diastolic volume (mL) 
      (14.88, 95% CI 2.88-26.76), LV end-systolic diameter (cm) (0.36, 95% CI 
      0.12-0.48), LV end-diastolic diameter (cm) (0.24, 95% CI 0.012-0.36), mitral 
      regurgitation (%) (3.12, 95% CI 0.48-5.76), and LV shape (0.036, 95% CI 
      0.012-0.060). In participants assigned to CRT, those without CKD had 
      significantly greater improvements in LV structural parameters compared with the 
      CKD group. CONCLUSIONS: In comparison with participants with normal kidney 
      function, CKD is an independent risk factor for ventricular dysfunction and 
      dilation. CRT improves LV function and structure to a lesser extent in patients 
      with CKD than in those with normal kidney function.
FAU - Mathew, Jehu
AU  - Mathew J
AD  - Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, 
      PA, USA.
FAU - Katz, Ronit
AU  - Katz R
FAU - St John Sutton, Martin
AU  - St John Sutton M
FAU - Dixit, Sanjay
AU  - Dixit S
FAU - Gerstenfeld, Edward P
AU  - Gerstenfeld EP
FAU - Ghio, Stefano
AU  - Ghio S
FAU - Gold, Michael R
AU  - Gold MR
FAU - Linde, Cecilia
AU  - Linde C
FAU - Shlipak, Michael G
AU  - Shlipak MG
FAU - Deo, Rajat
AU  - Deo R
LA  - eng
GR  - K23 DK089118/DK/NIDDK NIH HHS/United States
GR  - K23DK089118/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120906
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Chi-Square Distribution
MH  - Double-Blind Method
MH  - Echocardiography
MH  - Female
MH  - Heart Failure, Systolic/*physiopathology/*therapy
MH  - Humans
MH  - Kidney Failure, Chronic/*physiopathology
MH  - Kidney Function Tests
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Factors
MH  - Ventricular Dysfunction, Left/*physiopathology/*therapy
MH  - *Ventricular Remodeling
PMC - PMC3506959
EDAT- 2012/09/08 06:00
MHDA- 2013/05/29 06:00
PMCR- 2013/12/01
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - hfs135 [pii]
AID - 10.1093/eurjhf/hfs135 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2012 Dec;14(12):1420-8. doi: 10.1093/eurjhf/hfs135. Epub 2012 
      Sep 6.