PMID- 22957668
OWN - NLM
STAT- MEDLINE
DCOM- 20130815
LR  - 20211021
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 14
IP  - 2
DP  - 2013 Mar
TI  - Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet 
      autoantibodies in childhood and adolescent type 1 diabetes.
PG  - 97-105
LID - 10.1111/j.1399-5448.2012.00916.x [doi]
AB  - OBJECTIVE: To establish the diagnostic sensitivity of and the relationships 
      between autoantibodies to all three Zinc transporter 8 (Zinc transporter 8 
      autoantibody to either one, two, or all three amino acid variants at position 
      325, ZnT8A) variants to human leukocyte antigen (HLA)-DQ and to autoantibodies to 
      glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A), and 
      insulin (IAA). METHODS: We analyzed 3165 patients with type 1 diabetes (T1D) in 
      the Better Diabetes Diagnosis study for HLA-DQ genotypes and all six 
      autoantibodies (ZnT8RA, arginine 325 Zinc transporter 8 autoantibody; ZnT8WA, 
      tryptophan 325 Zinc transporter 8 autoantibody; ZnT8QA, glutamine 325 Zinc 
      transporter 8 autoantibody; GADA, IA-2A, and IAA). RESULTS: ZnT8A was found in 
      65% of the patients and as many as 108 of 3165 (3.4%) had 1-3 ZnT8A alone. None 
      had ZnT8QA alone. Together with GADA (56%), IA-2A (73%), and IAA (33%), 93% of 
      the T1D patients were autoantibody positive. All three ZnT8A were less frequent 
      in children below 2 yr of age (p < 0.0001). All three ZnT8A were associated with 
      DQA1-B1*X-0604 (DQ6.4) and DQA1-B1*03-0302 (DQ8). ZnT8WA and ZnT8QA were 
      negatively associated with DQA1-B1*05-02 (DQ2). CONCLUSIONS: Analysis of ZnT8A 
      increased the diagnostic sensitivity of islet autoantibodies for T1D as only 7% 
      remained islet autoantibody negative. The association between DQ6.4 and all three 
      ZnT8A may be related to ZnT8 antigen presentation by the DQ6.4 heterodimer.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Andersson, C
AU  - Andersson C
AD  - Department of Clinical Sciences, Lund University/CRC, Skane University Hospital 
      SUS, Malmo, Sweden. Cecilia_K.Andersson@med.lu.se
FAU - Vaziri-Sani, F
AU  - Vaziri-Sani F
FAU - Delli, Aj
AU  - Delli A
FAU - Lindblad, B
AU  - Lindblad B
FAU - Carlsson, A
AU  - Carlsson A
FAU - Forsander, G
AU  - Forsander G
FAU - Ludvigsson, J
AU  - Ludvigsson J
FAU - Marcus, C
AU  - Marcus C
FAU - Samuelsson, U
AU  - Samuelsson U
FAU - Ivarsson, Sa
AU  - Ivarsson S
FAU - Lernmark, A
AU  - Lernmark A
FAU - Larsson, H Elding
AU  - Larsson HE
CN  - BDD Study Group
LA  - eng
GR  - R01 DK026190/DK/NIDDK NIH HHS/United States
GR  - DK26190/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (Cation Transport Proteins)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ6 antigen)
RN  - 0 (SLC30A8 protein, human)
RN  - 0 (Zinc Transporter 8)
RN  - EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 8)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 2)
SB  - IM
MH  - Adolescent
MH  - Autoantibodies/*immunology
MH  - Cation Transport Proteins/genetics/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/genetics/*immunology
MH  - Female
MH  - Glutamate Decarboxylase/*immunology
MH  - HLA-DQ Antigens/*immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Receptor-Like Protein Tyrosine Phosphatases, Class 8/immunology
MH  - Zinc Transporter 8
FIR - Samuelsson, Bengt-Olof
IR  - Samuelsson BO
FIR - Snellman, Kalle
IR  - Snellman K
FIR - Olivecrona, Anna
IR  - Olivecrona A
FIR - Stenberg, Ake
IR  - Stenberg A
FIR - Skogsberg, Lars
IR  - Skogsberg L
FIR - Lindblad, Bengt
IR  - Lindblad B
FIR - Forsander, Gun
IR  - Forsander G
FIR - Neiderud, Jan
IR  - Neiderud J
FIR - Torbjornsdotter, Torun
IR  - Torbjornsdotter T
FIR - Hagg, Thomas
IR  - Hagg T
FIR - Hemmingsson, Kristina
IR  - Hemmingsson K
FIR - Akesson, Karin
IR  - Akesson K
FIR - Lundstrom, Goran
IR  - Lundstrom G
FIR - Ljungcrantz, Magnus
IR  - Ljungcrantz M
FIR - Forssberg, Maria
IR  - Forssberg M
FIR - Larsson, Karin
IR  - Larsson K
FIR - Gundewall, Christer
IR  - Gundewall C
FIR - Enander, Rebecka
IR  - Enander R
FIR - Samuelsson, Ulf
IR  - Samuelsson U
FIR - Carlsson, Annelie
IR  - Carlsson A
FIR - Nilsson, Anita
IR  - Nilsson A
FIR - Larsson, Helena E
IR  - Larsson HE
FIR - Ivarsson, Sten-A
IR  - Ivarsson SA
FIR - Brannstrom, Agneta
IR  - Brannstrom A
FIR - Nordwall, Maria
IR  - Nordwall M
FIR - Hellenberg, Lennart
IR  - Hellenberg L
FIR - Lundberg, Elena
IR  - Lundberg E
FIR - Bjorsell, Britta
IR  - Bjorsell B
FIR - Otqvist, Eva
IR  - Otqvist E
FIR - Kernell, Anna
IR  - Kernell A
FIR - Stjernstedt, Bjorn
IR  - Stjernstedt B
FIR - Wramner, Nils
IR  - Wramner N
FIR - Hanas, Ragnar
IR  - Hanas R
FIR - Swenne, Ingemar
IR  - Swenne I
FIR - Blomgren, Margareta
IR  - Blomgren M
FIR - Thastrom, Anders
IR  - Thastrom A
FIR - Arvidsson, C G
IR  - Arvidsson CG
FIR - Edvardsson, Stig
IR  - Edvardsson S
FIR - Jonsson, Bjorn
IR  - Jonsson B
FIR - Gadd, Torsten
IR  - Gadd T
FIR - Aman, Jan
IR  - Aman J
FIR - Florell, Rein
IR  - Florell R
FIR - Fureman, Anna-Lena
IR  - Fureman AL
EDAT- 2012/09/11 06:00
MHDA- 2013/08/16 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/02/14 00:00 [received]
PHST- 2012/06/08 00:00 [revised]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/08/16 06:00 [medline]
AID - 10.1111/j.1399-5448.2012.00916.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2013 Mar;14(2):97-105. doi: 10.1111/j.1399-5448.2012.00916.x. 
      Epub 2012 Sep 10.