PMID- 22957848
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20120917
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 49
IP  - 8
DP  - 2012 Oct
TI  - Association of urinary bisphenol A concentration with allergic asthma: results 
      from the National Health and Nutrition Examination Survey 2005-2006.
PG  - 800-6
LID - 10.3109/02770903.2012.721041 [doi]
AB  - OBJECTIVE: Bisphenol A (BPA) is being increasingly associated with adverse health 
      effects. Our objective was to determine whether urinary BPA concentration is 
      associated with allergic asthma in a representative US population. METHODS: Data 
      for this analysis were obtained from the National Health and Nutrition 
      Examination Survey 2005-2006 survey and included asthma-related questions, total 
      immunoglobulin E (IgE), 19 allergen-specific IgE levels, and urinary 
      environmental phenol measurements. Allergic asthma was defined as a history of 
      asthma ever, high eosinophil count, and high total IgE or atopy. Association 
      analyses included dichotomous and polychotomous logistic regression, receiver 
      operating characteristic curves, Akaike information criterion, and likelihood 
      ratio chi(2). RESULTS: We found that 10-fold increase in BPA was independently 
      associated with a higher likelihood of allergic asthma in females [odds ratio 
      (OR) = 2.21, p = .032] but not in males (OR = 0.83, p = .474). These findings 
      were reaffirmed when allergic asthma was defined based on atopy rather than total 
      IgE (OR = 2.45, p = .001 in females and OR = 0.83, p = .605 in males). Urinary 
      BPA was significantly associated with sensitization to various specific allergens 
      in a dose-response manner. Lastly, urinary BPA independently predicted an asthma 
      episode in the past 12 months in females but not in males. CONCLUSIONS: Urinary 
      BPA is significantly associated with allergic asthma in females.
FAU - Vaidya, Swapnil V
AU  - Vaidya SV
AD  - Lata Medical Research Foundation, Nagpur, India.
FAU - Kulkarni, Hemant
AU  - Kulkarni H
LA  - eng
PT  - Journal Article
DEP - 20120910
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Adult
MH  - Asthma/blood/*urine
MH  - Benzhydryl Compounds/*urine
MH  - Cell Count
MH  - Chi-Square Distribution
MH  - Eosinophils/immunology
MH  - Estrogens, Non-Steroidal/*urine
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Logistic Models
MH  - Male
MH  - Nutrition Surveys
MH  - Phenols/*urine
MH  - ROC Curve
MH  - Sex Factors
MH  - United States
EDAT- 2012/09/11 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.3109/02770903.2012.721041 [doi]
PST - ppublish
SO  - J Asthma. 2012 Oct;49(8):800-6. doi: 10.3109/02770903.2012.721041. Epub 2012 Sep 
      10.