PMID- 22958576
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20240406
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 12
DP  - 2012 Sep 10
TI  - Prevalence and correlations with depression, anxiety, and other features in 
      outpatients with chronic obstructive pulmonary disease in China: a 
      cross-sectional case control study.
PG  - 53
LID - 10.1186/1471-2466-12-53 [doi]
AB  - BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) often 
      experience depression and anxiety, but little information is available regarding 
      Chinese patients with these conditions. The present study assessed depression and 
      anxiety in Chinese patients with COPD. METHODS: A case-controlled study was 
      designed with 1100 patients with COPD enrolled in the case group and1100 
      residents without COPD and respiratory symptoms selected as the control group. 
      Anxiety and depression in both groups were evaluated using the Hospital Anxiety 
      and Depression Scale (HADS). The body mass index,degree of airflow obstruction, 
      dyspnea, and exercise capacity (BODE ) index was used to assess COPD severity. 
      Binary logistic regression models were used to test the association between 
      anxiety and depression. RESULTS: The patients with COPD were more likely than 
      controls to experience depression (cases, HADS 10.5 +/- 3.6, prevalence 35.7%; 
      controls, HADS 8.7 +/- 2.7, prevalence 7.2%) and anxiety (cases, HADS 10.4 +/- 3.1, 
      prevalence 18.3%; controls, HADS 8.6 +/- 2.1, prevalence 5.3%). Subjects with 
      anxious and depressive symptoms had poorer health outcomes including a higher 
      BODE index, a shorter 6-minute-walk distance (6MWD), more dyspnea, and a higher 
      St George's respiratory questionnaire (SGRQ) score. The prevalence of anxious and 
      depressive symptoms increased with increasing BODE scores. On the basis of binary 
      logistic regression, the BODE index was significantly correlated with anxiety (OR 
      = 1.47, p < 0.001) and depression (OR = 1.51, p < 0.001). Anxious and depressive 
      symptoms were also associated with several factors including younger age, female 
      sex, higher education level, lower household income and history of smoking. 
      CONCLUSIONS: This study confirmed the high prevalence of anxiety and depression 
      in Chinese outpatients with COPD. Patients with COPD who had anxiety and/or 
      depression had a poorer health-related quality of life. TRIAL REGISTRATION: 
      Chinese Clinical Trials Registration(ChiCTR-TRC-12001958).
FAU - Lou, Peian
AU  - Lou P
AD  - Xuzhou Center for Disease Control and Prevention, 142 West Erhuan Road, Xuzhou 
      221006, China. loupeian2004@yahoo.com.cn
FAU - Zhu, Yanan
AU  - Zhu Y
FAU - Chen, Peipei
AU  - Chen P
FAU - Zhang, Pan
AU  - Zhang P
FAU - Yu, Jiaxi
AU  - Yu J
FAU - Zhang, Ning
AU  - Zhang N
FAU - Chen, Na
AU  - Chen N
FAU - Zhang, Lei
AU  - Zhang L
FAU - Wu, Hongmin
AU  - Wu H
FAU - Zhao, Jing
AU  - Zhao J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anxiety/*epidemiology
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Depression/*epidemiology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Outpatients/*psychology
MH  - Prevalence
MH  - Pulmonary Disease, Chronic Obstructive/*epidemiology/*psychology
MH  - Quality of Life/psychology
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
PMC - PMC3503755
EDAT- 2012/09/11 06:00
MHDA- 2013/06/21 06:00
PMCR- 2012/09/10
CRDT- 2012/09/11 06:00
PHST- 2011/09/30 00:00 [received]
PHST- 2012/08/31 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
PHST- 2012/09/10 00:00 [pmc-release]
AID - 1471-2466-12-53 [pii]
AID - 10.1186/1471-2466-12-53 [doi]
PST - epublish
SO  - BMC Pulm Med. 2012 Sep 10;12:53. doi: 10.1186/1471-2466-12-53.