PMID- 22959466
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20220408
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 33
IP  - 34
DP  - 2012 Dec
TI  - The antimicrobial and osteoinductive properties of silver nanoparticle/poly 
      (DL-lactic-co-glycolic acid)-coated stainless steel.
PG  - 8745-56
LID - S0142-9612(12)00886-1 [pii]
LID - 10.1016/j.biomaterials.2012.08.010 [doi]
AB  - Implant-associated bacterial infections are one of the most serious complications 
      in orthopedic surgery. Treatment of these infections often requires multiple 
      operations, device removal, long-term systemic antibiotics, and extended 
      rehabilitation, and is frequently ineffective, leading to worse clinical outcomes 
      and increased financial costs. In this study, we evaluated silver 
      nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel 
      alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA 
      exhibited strong antibacterial activity in vitro and ex vivo, and promoted 
      MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, 
      SNPSA implants induced osteogenesis while suppressing bacterial survival in 
      contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous 
      antimicrobial and osteoinductive properties that make it a promising therapeutic 
      material in orthopedic surgery.
CI  - Published by Elsevier Ltd.
FAU - Liu, Yi
AU  - Liu Y
AD  - Shandong Provincial Laboratory of Oral Biomedicine, School and Hospital of 
      Stomatology, Shandong University, Jinan, Shandong 250012, PR China.
FAU - Zheng, Zhong
AU  - Zheng Z
FAU - Zara, Janette N
AU  - Zara JN
FAU - Hsu, Chingyun
AU  - Hsu C
FAU - Soofer, Donnalisa E
AU  - Soofer DE
FAU - Lee, Kevin S
AU  - Lee KS
FAU - Siu, Ronald K
AU  - Siu RK
FAU - Miller, Lloyd S
AU  - Miller LS
FAU - Zhang, Xinli
AU  - Zhang X
FAU - Carpenter, Doug
AU  - Carpenter D
FAU - Wang, Chunling
AU  - Wang C
FAU - Ting, Kang
AU  - Ting K
FAU - Soo, Chia
AU  - Soo C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120907
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 12597-68-1 (Stainless Steel)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 3M4G523W1G (Silver)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/*pharmacology
MH  - Bacteria/drug effects
MH  - Bacterial Infections/drug therapy/etiology
MH  - Coated Materials, Biocompatible/chemistry/*pharmacology
MH  - Femur/diagnostic imaging/growth & development/microbiology
MH  - Lactic Acid/chemistry
MH  - Male
MH  - Mice
MH  - Nanoparticles/chemistry
MH  - Osteoblasts/cytology
MH  - *Osteogenesis
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Prostheses and Implants/adverse effects
MH  - Radiography
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silver/chemistry/*pharmacology
MH  - Stainless Steel/chemistry
EDAT- 2012/09/11 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/06/06 00:00 [received]
PHST- 2012/08/05 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - S0142-9612(12)00886-1 [pii]
AID - 10.1016/j.biomaterials.2012.08.010 [doi]
PST - ppublish
SO  - Biomaterials. 2012 Dec;33(34):8745-56. doi: 10.1016/j.biomaterials.2012.08.010. 
      Epub 2012 Sep 7.