PMID- 22960342
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20211021
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 33
IP  - 4
DP  - 2012
TI  - Urinary chiro- and myo-inositol levels as a biological marker for type 2 diabetes 
      mellitus.
PG  - 193-9
LID - 10.3233/DMA-2012-0925 [doi]
AB  - BACKGROUND: The aim of this study was to investigate the role of the urinary 
      chiro- and myo-inositol levels in predicting type 2 diabetes mellitus (T2DM). 
      SUBJECTS AND METHODS: A total of 212 normal controls and 101 type 2 diabetic 
      patients were enrolled this study. The concentrations of urinary chiro- and 
      myo-inositol were measured by high performance liquid chromatography/mass 
      spectrometry. RESULTS: The concentration of urinary chiro-inositol was 
      significantly higher in the diabetic subjects (2.24 +/- 5.18 ng/L) than those in 
      the control group (0.38 +/- 0.62 ng/L; p < 0.001). The urinary myo-inositol level 
      of the diabetic subjects (36.95 +/- 37.77 ng/L) was also significantly higher than 
      that of the controls (8.17 +/- 13.29 ng/L; p < 0.001). The urinary chiro-inositol 
      multiplied by myo-inositol level of the diabetic subjects (148.10 +/- 544.91) was 
      significantly higher than in the controls (5.12 +/- 24.15; p < 0.001). The area 
      under the receiver operating characteristic curve for the urinary chiro-inositol 
      multiplied by myo-inositol level to predict T2DM was 0.840 (confidence interval 
      0.789-0.891, p < 0.001). The cut-off value for the urinary chiro-inositol 
      multiplied by myo-inositol level to predict T2DM was 2.20 (sensitivity 81.3%, 
      specificity 70.3%). CONCLUSIONS: The urinary chiro- and myo-inositol 
      concentrations were increased in the type 2 diabetic patients and the urinary 
      chiro- times the myo-inositol was considered to be a sufficient marker in 
      predicting T2DM.
FAU - Hong, Jun Hwa
AU  - Hong JH
AD  - Department of Internal Medicine, Chungnam National University School of Medicine, 
      Daejeon, Korea.
FAU - Jang, Hye Won
AU  - Jang HW
FAU - Kang, Yea Eun
AU  - Kang YE
FAU - Lee, Ju Hee
AU  - Lee JH
FAU - Kim, Koon Soon
AU  - Kim KS
FAU - Kim, Hyun Jin
AU  - Kim HJ
FAU - Park, Kyu Ri
AU  - Park KR
FAU - Ku, Bon Jeong
AU  - Ku BJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 4L6452S749 (Inositol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/urine
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*diagnosis/urine
MH  - Female
MH  - Humans
MH  - Inositol/*urine
MH  - Male
MH  - Middle Aged
PMC - PMC3810682
EDAT- 2012/09/11 06:00
MHDA- 2013/06/15 06:00
PMCR- 2012/11/09
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
PHST- 2012/11/09 00:00 [pmc-release]
AID - X03208172522KW60 [pii]
AID - 10.3233/DMA-2012-0925 [doi]
PST - ppublish
SO  - Dis Markers. 2012;33(4):193-9. doi: 10.3233/DMA-2012-0925.