PMID- 22961911
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20220408
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 114
IP  - 3
DP  - 2013 Mar
TI  - Recent agents targeting HIF-1alpha for cancer therapy.
PG  - 498-509
LID - 10.1002/jcb.24390 [doi]
AB  - The discovery of hypoxia-inducible factor-1 (HIF-1) has led to an increasing 
      understanding of the mechanism of tumor hypoxia in the past two decades. As a key 
      transcriptional regulator, HIF-1 plays a central role in the adaptation of tumor 
      cells to hypoxia by activating the transcription of targeting genes, which 
      regulate several biological processes including angiogenesis, cell proliferation, 
      survival, glucose metabolism and migration. The inhibitors of HIF-1 in cancer 
      have provided us a new clue for the targeting cancer therapy. This review will 
      introduce the general knowledge of the biology characteristic of HIF-1 and 
      mechanism of O(2)-dependent regulation. Moreover, a number of chemical inhibitors 
      plus protein and nucleic acid inhibitors are included and classified mainly based 
      on their different mechanism of inhibiting action. We also prefer to discuss the 
      advantages of protein and nucleic acid inhibitors compared with chemical 
      inhibitors.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Hu, Yaozhong
AU  - Hu Y
AD  - Department of Biochemical Engineering, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin 300072, China.
FAU - Liu, Jing
AU  - Liu J
FAU - Huang, He
AU  - Huang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Repressor Proteins)
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.14.11.- (HIF1AN protein, human)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Cell Hypoxia
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Gene Expression Regulation, Neoplastic
MH  - Glucose/metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & 
      inhibitors/chemistry/genetics/*metabolism
MH  - Mixed Function Oxygenases/metabolism
MH  - Molecular Targeted Therapy
MH  - Neoplasms/*drug therapy/metabolism
MH  - Neovascularization, Pathologic/*drug therapy
MH  - Protein Kinase Inhibitors/*metabolism
MH  - Repressor Proteins/metabolism
MH  - Transcription, Genetic
EDAT- 2012/09/11 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/05/11 00:00 [received]
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 10.1002/jcb.24390 [doi]
PST - ppublish
SO  - J Cell Biochem. 2013 Mar;114(3):498-509. doi: 10.1002/jcb.24390.