PMID- 22962838
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20200930
IS  - 1530-6992 (Electronic)
IS  - 1530-6984 (Linking)
VI  - 12
IP  - 10
DP  - 2012 Oct 10
TI  - Ultrasensitive flexible graphene based field-effect transistor (FET)-type 
      bioelectronic nose.
PG  - 5082-90
LID - 10.1021/nl301714x [doi]
AB  - Rapid and precise discrimination of various odorants is vital to fabricating 
      enhanced sensing devices in the fields of disease diagnostics, food safety, and 
      environmental monitoring. Here, we demonstrate an ultrasensitive and flexible 
      field-effect transistor (FET) olfactory system, namely, a bioelectronic nose 
      (B-nose), based on plasma-treated bilayer graphene conjugated with an olfactory 
      receptor. The stable p- and n-type behaviors from modified bilayer graphene 
      (MBLG) took place after controlled oxygen and ammonia plasma treatments. It was 
      integrated with human olfactory receptors 2AG1 (hOR2AG1: OR), leading to the 
      formation of the liquid-ion gated FET-type platform. ORs bind to the particular 
      odorant amyl butyrate (AB), and their interactions are specific and selective. 
      The B-noses behave as flexible and transparent sensing devices and can recognize 
      a target odorant with single-carbon-atom resolution. The B-noses are 
      ultrasensitive and highly selective toward AB. The minimum detection limit (MDL) 
      is as low as 0.04 fM (10(-15); signal-to-noise: 4.2), and the equilibrium 
      constants of OR-oxygen plasma-treated graphene (OR-OG) and ammonia plasma-treated 
      graphene (-NG) are ca. 3.44 x 10(14) and 1.47 x 10(14) M(-1), respectively. 
      Additionally, the B-noses have long-term stability and excellent mechanical 
      bending durability in flexible systems.
FAU - Park, Seon Joo
AU  - Park SJ
AD  - World Class University Program of Chemical Convergence for Energy & Environment, 
      School of Chemical and Biological Engineering, Seoul National University, Seoul 
      151-742, Korea.
FAU - Kwon, Oh Seok
AU  - Kwon OS
FAU - Lee, Sang Hun
AU  - Lee SH
FAU - Song, Hyun Seok
AU  - Song HS
FAU - Park, Tai Hyun
AU  - Park TH
FAU - Jang, Jyongsik
AU  - Jang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120913
PL  - United States
TA  - Nano Lett
JT  - Nano letters
JID - 101088070
RN  - 0 (Butyrates)
RN  - 0 (OR2AG1 protein, human)
RN  - 0 (Receptors, Odorant)
RN  - 0 (Recombinant Proteins)
RN  - 3Q2JP0VD8J (n-amyl butyrate)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Biosensing Techniques/*instrumentation/statistics & numerical data
MH  - Butyrates/analysis
MH  - *Graphite
MH  - Humans
MH  - Nanotechnology
MH  - Nose
MH  - Odorants/*analysis
MH  - Receptors, Odorant/metabolism
MH  - Recombinant Proteins/metabolism
MH  - Transistors, Electronic
EDAT- 2012/09/12 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 10.1021/nl301714x [doi]
PST - ppublish
SO  - Nano Lett. 2012 Oct 10;12(10):5082-90. doi: 10.1021/nl301714x. Epub 2012 Sep 13.