PMID- 22963539
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20161125
IS  - 1462-5822 (Electronic)
IS  - 1462-5814 (Linking)
VI  - 15
IP  - 2
DP  - 2013 Feb
TI  - Membrane dynamics and interactions in measles virus dendritic cell infections.
PG  - 161-9
LID - 10.1111/cmi.12025 [doi]
AB  - Viral entry, compartmentalization and transmission depend on the formation of 
      membrane lipid/protein microdomains concentrating receptors and signalosomes. 
      Dendritic cells (DCs) are prime targets for measles virus (MV) infection, and 
      this interaction promotes immune activation and generalized immunosuppression, 
      yet also MV transport to secondary lymphatics where transmission to T cells 
      occurs. In addition to MV trapping, DC-SIGN interaction can enhance MV uptake by 
      activating cellular sphingomyelinases and, thereby, vertical surface transport of 
      its entry receptor CD150. To exploit DCs as Trojan horses for transport, MV 
      promotes DC maturation accompanied by mobilization, and restrictions of viral 
      replication in these cells may support this process. MV-infected DCs are unable 
      to support formation of functional immune synapses with conjugating T cells and 
      signalling via viral glycoproteins or repulsive ligands (such as semaphorins) 
      plays a key role in the induction of T-cell paralysis. In the absence of antigen 
      recognition, MV transmission from infected DCs to T cells most likely involves 
      formation of polyconjugates which concentrate viral structural proteins, viral 
      receptors and with components enhancing either viral uptake or conjugate 
      stability. Because DCs barely support production of infectious MV particles, 
      these organized interfaces are likely to represent virological synapses essential 
      for MV transmission.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Avota, Elita
AU  - Avota E
AD  - Institute for Virology and Immunobiology, University of Wuerzburg, Versbacher 
      Str. 7, 97878 Wuerzburg, Germany.
FAU - Koethe, Susanne
AU  - Koethe S
FAU - Schneider-Schaulies, Sibylle
AU  - Schneider-Schaulies S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120928
PL  - India
TA  - Cell Microbiol
JT  - Cellular microbiology
JID - 100883691
RN  - 0 (Antigens, CD)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Virus)
RN  - 0 (SLAMF1 protein, human)
RN  - 0 (Viral Structural Proteins)
RN  - 169535-43-7 (Signaling Lymphocytic Activation Molecule Family Member 1)
RN  - EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
SB  - IM
MH  - Antigens, CD/genetics/metabolism
MH  - Cell Adhesion Molecules/genetics/metabolism
MH  - Cell Membrane/chemistry/*metabolism/virology
MH  - Dendritic Cells/immunology/*metabolism/virology
MH  - Gene Expression Regulation
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Lectins, C-Type/genetics/metabolism
MH  - Measles/immunology/*metabolism/transmission/virology
MH  - Measles virus/immunology/*metabolism
MH  - Receptors, Cell Surface/genetics/metabolism
MH  - Receptors, Virus/genetics/metabolism
MH  - Signal Transduction
MH  - Signaling Lymphocytic Activation Molecule Family Member 1
MH  - Sphingomyelin Phosphodiesterase/metabolism
MH  - T-Lymphocytes/pathology/virology
MH  - Viral Structural Proteins/genetics/metabolism
MH  - Virus Replication
EDAT- 2012/09/12 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/07/04 00:00 [received]
PHST- 2012/09/04 00:00 [revised]
PHST- 2012/09/04 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/cmi.12025 [doi]
PST - ppublish
SO  - Cell Microbiol. 2013 Feb;15(2):161-9. doi: 10.1111/cmi.12025. Epub 2012 Sep 28.