PMID- 22963634
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20190823
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 19
IP  - 29
DP  - 2012
TI  - Block copolymers for drug delivery nano systems (DDnSs).
PG  - 5088-100
AB  - The application of polymers in medicine, as components of drug carriers, as well 
      as their synthetic strategies are considered essential for producing and 
      developing new drug formulations against human deceases. The synthesis of block 
      copolymers is a timeconsuming process with a high cost of the final product, 
      although several block copolymer systems have been already commercialized 
      successfully. The biocompatibility, the biodegradability and the non toxic 
      profile of newly synthesized polymers towards healthy tissues, should be taken 
      into account in order to be acceptable for biomedical applications. In this 
      review article, focus is placed on new approaches and synthetic strategies for 
      preparing novel block copolymers and their utilization as parts of new and 
      advanced Drug Delivery nanoSystems (aDDnSs) with a Modulatory Controlled Release 
      profile (MCR). Such complex and advanced nanosystems can alter the 
      pharmacokinetic properties of the encapsulated drug and consequently its 
      effectiveness. Emphasis is given to the use of living polymerization 
      methodologies and post polymerization chemical transformation reactions for the 
      synthesis of mainly diblock copolymers for novel drug delivery nanosystems. 
      Issues related to self-assembly of block copolymers in solution toward formation 
      of colloidal functional nanostructures that can serve as nanocontainers and 
      nanocarriers, and strategies for controlling encapsulation of specific drugs are 
      also discussed. Specific examples are reported mainly on diblock copolymer 
      systems, including authors' recent work.
FAU - Kaditi, E
AU  - Kaditi E
AD  - Theoretical and Physical Chemistry Institute, National Hellenic Research 
      Foundation, 48 Vassileos Constantinou Avenue, 11635, Athens, Greece.
FAU - Mountrichas, G
AU  - Mountrichas G
FAU - Pispas, S
AU  - Pispas S
FAU - Demetzos, C
AU  - Demetzos C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Drug Carriers)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
SB  - IM
MH  - Biomedical Technology/methods
MH  - Drug Carriers/*administration & dosage/chemical synthesis/*chemistry
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Micelles
MH  - Models, Molecular
MH  - Nanotechnology/methods
MH  - Polymers/*administration & dosage/chemical synthesis/*chemistry
EDAT- 2012/09/12 06:00
MHDA- 2013/09/24 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/01/27 00:00 [received]
PHST- 2012/05/28 00:00 [revised]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - CMC-EPUB-20120903-16 [pii]
AID - 10.2174/0929867311209025088 [doi]
PST - ppublish
SO  - Curr Med Chem. 2012;19(29):5088-100. doi: 10.2174/0929867311209025088.