PMID- 22964969 OWN - NLM STAT- MEDLINE DCOM- 20130212 LR - 20151119 IS - 1473-558X (Electronic) IS - 0959-4965 (Linking) VI - 23 IP - 15 DP - 2012 Oct 24 TI - Kinetics of serum brain-derived neurotrophic factor following low-intensity versus high-intensity exercise in men and women. PG - 889-93 LID - 10.1097/WNR.0b013e32835946ca [doi] AB - Physical activity has been shown to enhance circulating brain-derived neurotrophic factor (BDNF) in animals and humans. However, the exact time course and sex-specific modulation of peripheral BDNF in response to exercise are still poorly understood. We examined the kinetics of BDNF serum concentrations in response to perceived high-intensity and low-intensity exercise, and during a subsequent recovery period by taking several blood samples during each phase. Furthermore, we compared the BDNF concentration between young men and women taking oral contraceptives. We found transient BDNF elevations during physical activity only for the high-intensity condition. Here, BDNF reached its maximum serum concentration after 20 min of exercise, and returned to baseline after approximately 10 min of recovery. Although there were no sex differences during baseline or recovery, the increase in the BDNF concentration during the exercise phase was more pronounced in men than in women. FAU - Schmidt-Kassow, Maren AU - Schmidt-Kassow M AD - aInstitute of Medical Psychology, Department of Sports Medicine, Goethe University, Frankfurt am Main, Germany. schmidt.kassow@yahoo.de FAU - Schadle, Sarah AU - Schadle S FAU - Otterbein, Sascha AU - Otterbein S FAU - Thiel, Christian AU - Thiel C FAU - Doehring, Alexandra AU - Doehring A FAU - Lotsch, Jorn AU - Lotsch J FAU - Kaiser, Jochen AU - Kaiser J LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Neuroreport JT - Neuroreport JID - 9100935 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Contraceptives, Oral, Hormonal) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Contraceptives, Oral, Hormonal/administration & dosage MH - Exercise/*physiology MH - Female MH - Humans MH - Male MH - Sex Characteristics MH - Sex Factors MH - Surveys and Questionnaires EDAT- 2012/09/12 06:00 MHDA- 2013/02/13 06:00 CRDT- 2012/09/12 06:00 PHST- 2012/09/12 06:00 [entrez] PHST- 2012/09/12 06:00 [pubmed] PHST- 2013/02/13 06:00 [medline] AID - 00001756-201210240-00005 [pii] AID - 10.1097/WNR.0b013e32835946ca [doi] PST - ppublish SO - Neuroreport. 2012 Oct 24;23(15):889-93. doi: 10.1097/WNR.0b013e32835946ca.