PMID- 22964975
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20211021
IS  - 1423-0151 (Electronic)
IS  - 1011-7571 (Print)
IS  - 1011-7571 (Linking)
VI  - 22
IP  - 2
DP  - 2013
TI  - Pioglitazone ameliorates endothelial dysfunction in those with impaired glucose 
      regulation among the first-degree relatives of type 2 diabetes mellitus patients.
PG  - 156-60
LID - 10.1159/000341770 [doi]
AB  - OBJECTIVE: To study the effects of pioglitazone on endothelial dysfunction of 
      subjects with impaired glucose regulation (IGR) among the first-degree relatives 
      of patients with type 2 diabetes mellitus (T2DM). SUBJECTS AND METHODS: The 
      first-degree relatives of T2DM patients were screened with oral glucose test and 
      IGR was diagnosed. IGR subjects whose blood glucose was still above the level 
      after 1-month exercise were randomized to receive pioglitazone (15 mg/day) or 
      vehicle for 12 weeks. Endothelial function was assessed as endothelium-dependent 
      and -independent vasodilation. Blood nitric oxide (NO), blood pressure, body mass 
      index, insulin and serum lipids were also measured. Area under the curve of 
      glucose (AUC(glu)) and insulin (AUC(INS)), homeostasis model assessment of 
      insulin resistance (HOMA-IR), HOMA of beta-cell function (HOMA-beta) and early insulin 
      secretion index (DeltaI(30)/DeltaG(30)) were calculated. RESULTS: After pioglitazone 
      treatment, fasting plasma, 2-hour plasma glucose, triglyceride (TG), fasting 
      insulin, AUC(glu), HOMA-beta and HOMA-IR, 2-hour insulin, AUC(INS) and DeltaI(30)/DeltaG(30) 
      decreased. Endothelium-dependent vasodilation and NO were significantly improved 
      in the treatment group. Furthermore, the changes of endothelium-dependent 
      vasodilation were negatively correlated with changes in AUC(INS) but positively 
      with NO and HOMA-beta. Stepwise multivariate regression analysis showed that changes 
      in NO and HOMA-beta were both independent parameters for improvement of endothelial 
      dysfunction. CONCLUSION: Pioglitazone decreased blood glucose and TG, increased 
      insulin sensitivity, and ameliorated endothelial dysfunction of IGR subjects 
      among the first-degree relatives of T2DM patients. Increased NO production may be 
      associated with the improvement of endothelial dysfunction.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Yu, Xuemei
AU  - Yu X
AD  - Department of Endocrinology, Fengxian Central Hospital, Shanghai, PR China.
FAU - Chen, Peihong
AU  - Chen P
FAU - Wang, Hongtao
AU  - Wang H
FAU - Zhu, Tong
AU  - Zhu T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120904
PL  - Switzerland
TA  - Med Princ Pract
JT  - Medical principles and practice : international journal of the Kuwait University, 
      Health Science Centre
JID - 8901334
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Thiazolidinediones)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - X4OV71U42S (Pioglitazone)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/*genetics/physiopathology
MH  - Double-Blind Method
MH  - Endothelium, Vascular/*drug effects
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/blood
MH  - Pioglitazone
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Thiazolidinediones/*therapeutic use
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler, Color
PMC - PMC5586722
EDAT- 2012/09/12 06:00
MHDA- 2013/08/24 06:00
PMCR- 2012/09/04
CRDT- 2012/09/12 06:00
PHST- 2011/11/21 00:00 [received]
PHST- 2012/07/08 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
PHST- 2012/09/04 00:00 [pmc-release]
AID - 000341770 [pii]
AID - mpp-0022-0156 [pii]
AID - 10.1159/000341770 [doi]
PST - ppublish
SO  - Med Princ Pract. 2013;22(2):156-60. doi: 10.1159/000341770. Epub 2012 Sep 4.