PMID- 22965071
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20220408
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Linking)
VI  - 10
IP  - 2
DP  - 2013 Mar
TI  - CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 
      2 diabetes and its complications.
PG  - 115-22
LID - 10.1177/1479164112455817 [doi]
AB  - Numerous epidemiological studies have consistently demonstrated the strong 
      association between type 2 diabetes mellitus (T2DM) and an increased risk to 
      develop cardiovascular disease. The pathogenesis of T2DM and its complications 
      are characterized by pancreatic, adipose tissue and vascular inflammation. CD40 
      and CD40L, members of the tumour necrosis factor (receptor) TNF(R) family, are 
      well known for their role in immunity and inflammation. Here we give an overview 
      on the role of CD40-CD40L interactions in the pathogenesis of T2DM with a special 
      focus on pancreatic, adipose tissue and vascular inflammation. In addition, we 
      explore the role of soluble CD40L (sCD40L) as a potential biomarker for the 
      development of cardiovascular disease in T2DM subjects. Finally, the therapeutic 
      potential of CD40-CD40L inhibition in T2DM is highlighted.
FAU - Seijkens, Tom
AU  - Seijkens T
AD  - Department of Medical Biochemistry, Academic Medical Center, University of 
      Amsterdam, Amsterdam, The Netherlands. t.t.seijkens@amc.uva.nl
FAU - Kusters, Pascal
AU  - Kusters P
FAU - Engel, David
AU  - Engel D
FAU - Lutgens, Esther
AU  - Lutgens E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120910
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (CD40 Antigens)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Adipose Tissue/*immunology
MH  - CD40 Antigens/*immunology
MH  - CD40 Ligand/*immunology
MH  - Diabetes Mellitus, Type 2/complications/*immunology
MH  - Humans
MH  - Pancreatitis/etiology/*immunology
MH  - Vasculitis/etiology/*immunology
EDAT- 2012/09/12 06:00
MHDA- 2013/08/10 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
AID - 1479164112455817 [pii]
AID - 10.1177/1479164112455817 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2013 Mar;10(2):115-22. doi: 10.1177/1479164112455817. Epub 
      2012 Sep 10.