PMID- 22965361
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20231103
IS  - 1806-9460 (Electronic)
IS  - 1516-3180 (Print)
IS  - 1516-3180 (Linking)
VI  - 130
IP  - 4
DP  - 2012
TI  - Association between human leukocyte antigens and graft-versus-host disease 
      occurrence after allogenic hematopoietic stem cell transplantation.
PG  - 219-24
LID - S1516-31802012000400003 [pii]
AB  - CONTEXT AND OBJECTIVE: Graft-versus-host disease (GVHD) is one of the 
      complications following allogenic stem cell transplantation. This study 
      investigated an association between human leukocyte antigen (HLA) and the 
      occurrence of acute and chronic GVHD in patients who had received stem cell 
      transplantations from HLA-identical siblings. DESIGN AND SETTING: Retrospective 
      study at Hematology and Hemotherapy Center, Universidade Estadual de Campinas 
      (Unicamp). METHODS: The participants were 176 patients whose first transplant was 
      between 1997 and 2009. HLA genotyping was performed serologically and using the 
      polymerase chain reaction with specific primer sequence. RESULTS: Acute GVHD was 
      positively associated with HLA-A10 (P = 0.0007), HLA-A26 (P = 0.002), B55 (P = 
      0.001), DRB1*15 (P = 0.0211) and DQB1*05 (P = 0.038), while HLA-B16 (P = 0.0333) 
      was more frequent in patients without acute GVHD. Chronic GVHD was positively 
      associated with HLA-A9 (P = 0.01) and A23 (P = 0.0292) and negatively with HLA-A2 
      (P = 0.0031) and B53 (P = 0.0116). HLA-B35 (P = 0.0373), B49 (P = 0.0155) and B55 
      (P = 0.0024) were higher in patients with acute GVHD grade 3 or above, than in 
      other patients. In patients with extensive chronic GVHD, HLA-A9 (P = 0.0004), A24 
      (P = 0.0059) and A26 (P = 0.0411) were higher than in other patients, while 
      HLA-A2 was lower (P = 0.0097). CONCLUSION: This study suggests that HLA can 
      influence the incidence and severity of acute and chronic GVHD. However, a study 
      with a better design and more patients will be needed to confirm these results.
FAU - Cardozo, Daniela Maira
AU  - Cardozo DM
AD  - Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil.
FAU - Lieber, Sofia Rocha
AU  - Lieber SR
FAU - Marques, Silvia Barbosa Dutra
AU  - Marques SB
FAU - Aranha, Francisco Jose
AU  - Aranha FJ
FAU - Vigorito, Afonso Celso
AU  - Vigorito AC
FAU - Souza, Carmino Antonio de
AU  - Souza CA
FAU - Visentainer, Jeane Eliete Laguila
AU  - Visentainer JE
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Sao Paulo Med J
JT  - Sao Paulo medical journal = Revista paulista de medicina
JID - 100897261
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Female
MH  - Gene Frequency
MH  - Graft vs Host Disease/genetics/*immunology
MH  - HLA Antigens/genetics/*immunology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Infant
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Transplantation, Homologous/adverse effects/immunology
MH  - Young Adult
PMC - PMC10619959
COIS- Conflict of interest: None
EDAT- 2012/09/12 06:00
MHDA- 2013/06/07 06:00
PMCR- 2012/09/04
CRDT- 2012/09/12 06:00
PHST- 2010/01/21 00:00 [received]
PHST- 2011/12/19 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
PHST- 2012/09/04 00:00 [pmc-release]
AID - S1516-31802012000400003 [pii]
AID - 10.1590/s1516-31802012000400003 [doi]
PST - ppublish
SO  - Sao Paulo Med J. 2012;130(4):219-24. doi: 10.1590/s1516-31802012000400003.