PMID- 22965551
OWN - NLM
STAT- MEDLINE
DCOM- 20130904
LR  - 20240322
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 223
IP  - 2
DP  - 2012 Nov
TI  - Self-enhancement processing in the default network: a single-pulse TMS study.
PG  - 177-87
LID - 10.1007/s00221-012-3249-7 [doi]
AB  - Much research has been done on positive self-evaluation and its relationship to 
      mental health. However, little is known about its neural underpinnings. Imaging 
      studies have suggested that the brain's default network is involved with 
      self-related processing and that one portion of the default network, medial 
      prefrontal cortex (MPFC), is particularly involved with self-evaluation. Here, we 
      used transcranial magnetic stimulation (TMS) to causally demonstrate that this 
      network, and particularly MPFC, is involved with self-evaluative processing. In a 
      first experiment, 27 healthy volunteers judged whether adjectives, evenly divided 
      between desirable and undesirable traits, described themselves or their best 
      friends, and a robust self-enhancement bias effect was found. In a second 
      experiment, single-pulse TMS was applied targeting three locations (MPFC and left 
      and right parietal cortex) in a different group of healthy volunteers while they 
      performed the adjective task. In each trial, TMS was applied at one of five 
      different times relative to onset of the adjective ranging from 0 to 480 ms. TMS 
      affected self-enhancement bias in a site- and latency-specific manner: at MPFC, 
      the self-enhancement bias actually reversed at 160 ms, with subjects favoring 
      their best friend over themselves. TMS may thus be of use in investigating areas 
      of mental illness in which self-evaluation is abnormal, potentially as a 
      diagnostic tool. In addition, the present study, combined with our previous 
      reports (Lou et al., Proc Natl Acad Sci USA 101(17):6827-6832, 2004, Exp Brain 
      Res 207:27-38, 2010), causally demonstrates two kinds of self-related processing 
      within the default network, one centered in parietal cortex and concerned with 
      retrieval of self-related associations, and the other MPFC-centered and involved 
      in self-evaluative processing.
FAU - Luber, Bruce
AU  - Luber B
AD  - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 
      Box 3620, Durham, NC 27710, USA. bruce.luber@duke.edu
FAU - Lou, Hans C
AU  - Lou HC
FAU - Keenan, Julian P
AU  - Keenan JP
FAU - Lisanby, Sarah H
AU  - Lisanby SH
LA  - eng
GR  - K01 AG031912/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120911
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain/*physiology
MH  - *Brain Mapping
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Male
MH  - Models, Neurological
MH  - Reaction Time/physiology
MH  - *Self Concept
MH  - Task Performance and Analysis
MH  - Time Factors
MH  - *Transcranial Magnetic Stimulation
PMC - PMC4055952
MID - NIHMS407024
EDAT- 2012/09/12 06:00
MHDA- 2013/09/05 06:00
PMCR- 2014/06/13
CRDT- 2012/09/12 06:00
PHST- 2012/06/11 00:00 [received]
PHST- 2012/08/25 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/09/05 06:00 [medline]
PHST- 2014/06/13 00:00 [pmc-release]
AID - 10.1007/s00221-012-3249-7 [doi]
PST - ppublish
SO  - Exp Brain Res. 2012 Nov;223(2):177-87. doi: 10.1007/s00221-012-3249-7. Epub 2012 
      Sep 11.