PMID- 22966150
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20221207
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 38
IP  - 6
DP  - 2012 Nov
TI  - Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious 
      exposure.
PG  - 1149-54
LID - 10.1093/schbul/sbs087 [doi]
AB  - BACKGROUND: Genome-wide association studies (GWAS) implicate single nucleotide 
      polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) 
      region, as common risk factors for schizophrenia (SZ). Other studies implicate 
      viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on 
      SZ risk with and without exposure. METHOD: GWAS-significant SNPs and 
      ancestry-informative marker SNPs were analyzed among African American patients 
      with SZ (n = 604) and controls (n = 404). Exposure to herpes simplex virus, type 
      1 (HSV-1), cytomegalovirus (CMV), and Toxoplasma gondii (TOX) was assayed using 
      specific antibody assays. RESULTS: Five SNPs were nominally associated with SZ, 
      adjusted for population admixture (P < .05, uncorrected for multiple 
      comparisons). These SNPs were next analyzed in relation to infectious exposure. 
      Multivariate analysis indicated significant association between rs3130297 
      genotype and HSV-1 exposure; the associated allele was different from the SZ risk 
      allele. CONCLUSIONS: We propose a model for the genesis of SZ incorporating 
      genomic variation in the HLA region and neurotropic viral exposure for testing in 
      additional, independent African American samples.
FAU - Bamne, Mikhil
AU  - Bamne M
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, Western 
      Psychiatric Institute and Clinic, Pittsburgh, PA, USA.
FAU - Wood, Joel
AU  - Wood J
FAU - Chowdari, Kodavali
AU  - Chowdari K
FAU - Watson, Annie M
AU  - Watson AM
FAU - Celik, Cemil
AU  - Celik C
FAU - Mansour, Hader
AU  - Mansour H
FAU - Klei, Lambertus
AU  - Klei L
FAU - Gur, Ruben C
AU  - Gur RC
FAU - Bradford, L DiAnne
AU  - Bradford LD
FAU - Calkins, Monica E
AU  - Calkins ME
FAU - Santos, Alberto B
AU  - Santos AB
FAU - Edwards, Neil
AU  - Edwards N
FAU - Kwentus, Joseph
AU  - Kwentus J
FAU - McEvoy, Joseph P
AU  - McEvoy JP
FAU - Allen, Trina B
AU  - Allen TB
FAU - Savage, Robert M
AU  - Savage RM
FAU - Nasrallah, Henry A
AU  - Nasrallah HA
FAU - Gur, Raquel E
AU  - Gur RE
FAU - Perry, Rodney T
AU  - Perry RT
FAU - Go, Rodney C P
AU  - Go RC
FAU - Devlin, Bernie
AU  - Devlin B
FAU - Yolken, Robert
AU  - Yolken R
FAU - Nimgaonkar, Vishwajit L
AU  - Nimgaonkar VL
LA  - eng
GR  - R01 MH066049/MH/NIMH NIH HHS/United States
GR  - R01 MH66050/MH/NIMH NIH HHS/United States
GR  - R01 MH66181-03/MH/NIMH NIH HHS/United States
GR  - R01 MH66004/MH/NIMH NIH HHS/United States
GR  - R01 MH66121/MH/NIMH NIH HHS/United States
GR  - MH66006/MH/NIMH NIH HHS/United States
GR  - R01 MH66263/MH/NIMH NIH HHS/United States
GR  - R01 MH066005/MH/NIMH NIH HHS/United States
GR  - MH66278/MH/NIMH NIH HHS/United States
GR  - K08 MH79364/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
RN  - 0 (BTN3A2 protein, human)
RN  - 0 (Butyrophilins)
RN  - 0 (HLA Antigens)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Adult
MH  - Black or African American/genetics/psychology
MH  - Butyrophilins
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 6
MH  - Cytomegalovirus
MH  - Cytomegalovirus Infections
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Herpes Simplex/complications
MH  - Herpesvirus 1, Human
MH  - Humans
MH  - Male
MH  - Membrane Proteins/genetics
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Schizophrenia/*genetics/parasitology/virology
MH  - Toxoplasmosis, Cerebral/complications
PMC - PMC3494045
EDAT- 2012/09/12 06:00
MHDA- 2013/05/17 06:00
PMCR- 2013/11/01
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - sbs087 [pii]
AID - 10.1093/schbul/sbs087 [doi]
PST - ppublish
SO  - Schizophr Bull. 2012 Nov;38(6):1149-54. doi: 10.1093/schbul/sbs087. Epub 2012 Sep 
      10.