PMID- 22967840
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220311
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Glucocorticoid regulation of brain-derived neurotrophic factor: relevance to 
      hippocampal structural and functional plasticity.
PG  - 196-213
LID - S0306-4522(12)00900-1 [pii]
LID - 10.1016/j.neuroscience.2012.08.065 [doi]
AB  - Glucocorticoids serve as key stress response hormones that facilitate stress 
      coping. However, sustained glucocorticoid exposure is associated with adverse 
      consequences on the brain, in particular within the hippocampus. Chronic 
      glucocorticoid exposure evokes neuronal cell damage and dendritic atrophy, 
      reduces hippocampal neurogenesis and impairs synaptic plasticity. Glucocorticoids 
      also alter expression and signaling of the neurotrophin, brain-derived 
      neurotrophic factor (BDNF). Since BDNF is known to promote neuroplasticity, 
      enhance cell survival, increase hippocampal neurogenesis and cellular 
      excitability, it has been hypothesized that specific adverse effects of 
      glucocorticoids may be mediated by attenuating BDNF expression and signaling. The 
      purpose of this review is to summarize the current state of literature examining 
      the influence of glucocorticoids on BDNF, and to address whether specific effects 
      of glucocorticoids arise through perturbation of BDNF signaling. We integrate 
      evidence of glucocorticoid regulation of BDNF at multiple levels, spanning from 
      the well-documented glucocorticoid-induced changes in BDNF mRNA to studies 
      examining alterations in BDNF receptor-mediated signaling. Further, we delineate 
      potential lines of future investigation to address hitherto unexplored aspects of 
      the influence of glucocorticoids on BDNF. Finally, we discuss the current 
      understanding of the contribution of BDNF to the modulation of structural and 
      functional plasticity by glucocorticoids, in particular in the context of the 
      hippocampus. Understanding the mechanistic crosstalk between glucocorticoids and 
      BDNF holds promise for the identification of potential therapeutic targets for 
      disorders associated with the dysfunction of stress hormone pathways.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Suri, D
AU  - Suri D
AD  - Department of Biological Sciences, Tata Institute of Fundamental Research, Homi 
      Bhabha Road, Colaba, Mumbai 400005, India.
FAU - Vaidya, V A
AU  - Vaidya VA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120909
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Glucocorticoids/*metabolism
MH  - Hippocampus/*cytology/*metabolism
MH  - Humans
MH  - Neuronal Plasticity/*physiology
MH  - Signal Transduction/physiology
EDAT- 2012/09/13 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/08/28 00:00 [revised]
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0306-4522(12)00900-1 [pii]
AID - 10.1016/j.neuroscience.2012.08.065 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:196-213. doi: 10.1016/j.neuroscience.2012.08.065. 
      Epub 2012 Sep 9.