PMID- 22968324
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20180813
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 24
IP  - 6
DP  - 2012 Dec
TI  - Vitamin D status and oxidative stress markers in the elderly with impaired 
      fasting glucose and type 2 diabetes mellitus.
PG  - 595-602
LID - 10.3275/8591 [doi]
AB  - BACKGROUND AND AIMS: Vitamin D deficiency has been identified in the elderly as a 
      potential risk factor for cardiovascular disease development, possibly through 
      its association with other risk factors, such as type 2 diabetes mellitus (T2DM), 
      hypercholesterolemia and hypertension. The aim of this cross-sectional study was 
      to evaluate the vitamin D status in elderly subjects with impaired fasting 
      glucose (IFG) or T2DM, and to examine its relationships to systemic oxidative 
      stress and biochemical markers of endothelial dysfunction. METHODS: Serum 
      25-hydroxyvitamin D [25(OH)D], fasting glucose, insulin, lipid profile, advanced 
      glycation end products (AGEs), advanced oxidation protein products (AOPPs), 
      low-density lipoprotein susceptibility to oxidation (oxLDL) and nitric oxide 
      metabolic pathway products (NOx) were analyzed in elderly subjects with IFG 
      (n=30) and T2DM (n=35) compared with aged-matched controls (n=25). RESULTS: 
      25(OH)D levels in the IFG and T2DM groups were significantly lower than in 
      controls (31.9+/-1.9 and 28.5+/-1.9 vs 39.4+/-2.4 ng/mL, p<0.001), and associated with 
      significantly (p<0.001) higher levels of the oxidative stress parameters AGEs, 
      AOPPs, oxLDL and NOx. Hypovitaminosis D [25(OH)D)<30 ng/ml] markedly enhanced the 
      oxidative stress and cardiovascular risk in hyperglycemic subjects compared with 
      sufficient vitamin D [25(OH)D)>/=30 ng/mL] status subjects. In subjects with IFG 
      and T2DM (n=65), the vitamin D status was significantly inversely correlated both 
      with oxLDL (r=-0.413, p=0.001) and AOPPs (r=-0.475, p<0.001), and strongly 
      positively associated with highdensity lipoprotein cholesterol (r=0.609, 
      p<0.001). CONCLUSIONS: In the elderly with impaired glucose metabolism the 
      vitamin D status is inversely associated with levels of circulating markers of 
      oxidative stress and endothelial dysfunction, especially in subjects with 
      hypovitaminosis D.
FAU - Gradinaru, Daniela
AU  - Gradinaru D
AD  - Ana Aslan National Institute of Gerontology and Geriatrics, Bucharest, Romania. 
      danielagrdnr@yahoo.com
FAU - Borsa, Claudia
AU  - Borsa C
FAU - Ionescu, Cristina
AU  - Ionescu C
FAU - Margina, Denisa
AU  - Margina D
FAU - Prada, Gabriel I
AU  - Prada GI
FAU - Jansen, Eugene
AU  - Jansen E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Aged
MH  - Aging/blood
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/etiology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/etiology
MH  - Fasting/blood
MH  - Female
MH  - Glucose Metabolism Disorders/*blood/etiology
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Oxidative Stress
MH  - Risk Factors
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/complications
EDAT- 2012/09/13 06:00
MHDA- 2013/09/17 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - 8591 [pii]
AID - 10.3275/8591 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2012 Dec;24(6):595-602. doi: 10.3275/8591. Epub 2012 Sep 10.