PMID- 22969227
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20211021
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 33
DP  - 2012 Sep 7
TI  - Efficacy of a therapeutic strategy for eradication of Helicobacter pylori 
      infection.
PG  - 4542-8
LID - 10.3748/wjg.v18.i33.4542 [doi]
AB  - AIM: To determine the efficacy of our therapeutic strategy for Helicobacter 
      pylori (H. pylori) eradication and to identify predictive factors for successful 
      eradication. METHODS: From April 2006 to June 2010, we retrospectively assessed 
      2428 consecutive patients (1025 men, 1403 women; mean age 55 years, age range 
      18-92 years) with gastric histology positive for H. pylori infection referred to 
      our unit for 13-C urea breath test (UBT), after first-line therapy with proton 
      pump inhibitor (PPI) b.i.d. + amoxicillin 1 g b.i.d. + clarithromycin 500 mg 
      b.i.d. for 7 d. Patients who were still positive to UBT were recommended a 
      second-line therapy (PPI b.i.d. + amoxicillin 1 g b.i.d. + tinidazole 500 mg 
      b.i.d. for 14 d). Third choice treatment was empirical with PPI b.i.d. + 
      amoxicillin 1 g b.i.d. + levofloxacin 250 mg b.i.d. for 14 d. RESULTS: Out of 614 
      patients, still H. pylori-positive after first-line therapy, only 326 and 19 
      patients respectively rechecked their H. pylori status by UBT after the suggested 
      second and third-line regimens. "Per protocol" eradication rates for first, 
      second and third-line therapy were 74.7% (95% CI: 72.7%-76.4%), 85.3% (95% CI: 
      81.1%-89.1%) and 89.5% (95% CI: 74.9%-103%) respectively. The overall percentage 
      of patients with H. pylori eradicated after two treatments was 97.8% (95% CI: 
      97.1%-98.4%), vs 99.9% (95% CI: 99.8%-100%) after three treatments. The study 
      found that eradication therapy was most effective in patients with ulcer disease 
      (P < 0.05, P = 0.028), especially in those with duodenal ulcer. Smoking habits 
      did not significantly affect the eradication rate. CONCLUSION: First-line therapy 
      with amoxicillin and clarithromycin produces an H. pylori eradication rate 
      comparable or superior to other studies and second-line treatment can still be 
      triple therapy with amoxicillin and tinidazole.
FAU - Sereni, Giuliana
AU  - Sereni G
AD  - Unit of Gastroenterology and Digestive Endoscopy, Arcispedale Santa Maria Nuova, 
      Istituto di Ricovero e Cura a Carattere Scientifico, 42123 Reggio Emilia, Italy. 
      giuliana.sereni@asmn.re.it
FAU - Azzolini, Francesco
AU  - Azzolini F
FAU - Camellini, Lorenzo
AU  - Camellini L
FAU - Formisano, Debora
AU  - Formisano D
FAU - Decembrino, Francesco
AU  - Decembrino F
FAU - Iori, Veronica
AU  - Iori V
FAU - Tioli, Cristiana
AU  - Tioli C
FAU - Cavina, Maurizio
AU  - Cavina M
FAU - Di Mario, Francesco
AU  - Di Mario F
FAU - Bedogni, Giuliano
AU  - Bedogni G
FAU - Sassatelli, Romano
AU  - Sassatelli R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Proton Pump Inhibitors)
RN  - 033KF7V46H (Tinidazole)
RN  - 6GNT3Y5LMF (Levofloxacin)
RN  - 804826J2HU (Amoxicillin)
RN  - A4P49JAZ9H (Ofloxacin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amoxicillin/*therapeutic use
MH  - Breath Tests
MH  - Clarithromycin/*therapeutic use
MH  - Comorbidity
MH  - Disease Eradication/*methods
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Female
MH  - Helicobacter Infections/*drug therapy/epidemiology/*prevention & control
MH  - *Helicobacter pylori
MH  - Humans
MH  - Levofloxacin
MH  - Male
MH  - Middle Aged
MH  - Ofloxacin/therapeutic use
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Tinidazole/therapeutic use
MH  - Treatment Outcome
MH  - Ulcer/drug therapy/epidemiology/microbiology
MH  - Young Adult
PMC - PMC3435779
OTO - NOTNLM
OT  - Eradication rate
OT  - Eradication treatment
OT  - First-line therapy
OT  - Helicobacter pylori
OT  - Rescue therapy
OT  - Second-line therapy
OT  - Triple therapy
EDAT- 2012/09/13 06:00
MHDA- 2013/04/17 06:00
PMCR- 2012/09/07
CRDT- 2012/09/13 06:00
PHST- 2011/12/31 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/05/26 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
PHST- 2012/09/07 00:00 [pmc-release]
AID - 10.3748/wjg.v18.i33.4542 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Sep 7;18(33):4542-8. doi: 10.3748/wjg.v18.i33.4542.