PMID- 22969250
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211021
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 27
IP  - 9
DP  - 2012 Sep
TI  - Index of microcirculatory resistance as predictor for microvascular functional 
      recovery in patients with anterior myocardial infarction.
PG  - 1044-50
LID - 10.3346/jkms.2012.27.9.1044 [doi]
AB  - IMR is useful for assessing the microvascular dysfunction after primary 
      percutaneous coronary intervention (PCI). It remains unknown whether index of 
      microcirculatory resistance (IMR) reflects the functional outcome in patients 
      with anterior myocardial infarction (AMI) with or without microvascular 
      obstruction (MO).This study was performed to evaluate the clinical value of the 
      IMR for assessing myocardial injury and predicting microvascular functional 
      recovery in patients with AMI undergoing primary PCI. We enrolled 34 patients 
      with first anterior AMI. After successful primary PCI, the mean distal coronary 
      artery pressure (P(a)), coronary wedge pressure (P(cw)), mean aortic pressure 
      (P(a)), mean transit time (T(mn)), and IMR (P(d)* hyperemic T(mn)) were measured. 
      The presence and extent of MO were measured using cardiac magnetic resonance 
      image (MRI). All patients underwent follow-up echocardiography after 6 months. We 
      divided the patients into two groups according to the existence of MO (present; n 
      = 16, absent; n = 18) on MRI. The extent of MO correlated with IMR (r = 0.754; P 
      < 0.001), P(cw) (r = 0.404; P = 0.031), and P(cw)/P(d) of infarct-related 
      arteries (r = 0.502; P = 0.016). The IMR was significantly correlated with the 
      DeltaRegional wall motion score index (r = -0.61, P < 0.01) and DeltaLeft ventricular 
      ejection fraction (r = -0.52, P < 0.01), implying a higher IMR is associated with 
      worse functional improvement. Therefore, Intracoronary wedge pressures and IMR, 
      as parameters for specific and quantitative assessment of coronary microvascular 
      dysfunction, are reliable on-site predictors of short-term myocardial viability 
      and Left ventricle functional recovery in patients undergoing primary PCI for 
      AMI.
FAU - Yoo, Seung-Hoon
AU  - Yoo SH
AD  - Department of Cardiology, Kwandong University School of Medicine, Goyang, Korea.
FAU - Yoo, Tae-Kyung
AU  - Yoo TK
FAU - Lim, Hong-Seok
AU  - Lim HS
FAU - Kim, Mi-Young
AU  - Kim MY
FAU - Koh, Jong-Hoon
AU  - Koh JH
LA  - eng
PT  - Journal Article
DEP - 20120822
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anterior Wall Myocardial Infarction/*physiopathology
MH  - Arterial Pressure/physiology
MH  - Coronary Occlusion/pathology
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Microcirculation/*physiology
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - *Predictive Value of Tests
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Risk Factors
PMC - PMC3429821
OTO - NOTNLM
OT  - Acute Anterior Wall Myocardial Infarction
OT  - Capillary Resistance
OT  - Coronary Occlusion
OT  - Magnetic Resonance Imaging
EDAT- 2012/09/13 06:00
MHDA- 2013/01/17 06:00
PMCR- 2012/09/01
CRDT- 2012/09/13 06:00
PHST- 2011/11/30 00:00 [received]
PHST- 2012/06/26 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - 10.3346/jkms.2012.27.9.1044 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2012 Sep;27(9):1044-50. doi: 10.3346/jkms.2012.27.9.1044. Epub 
      2012 Aug 22.