PMID- 22970898
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20191210
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 18
IP  - 1
DP  - 2013 Jan
TI  - Cue reactivity and its inhibition in pathological computer game players.
PG  - 134-46
LID - 10.1111/j.1369-1600.2012.00491.x [doi]
AB  - Despite a rising social relevance of pathological computer game playing, it 
      remains unclear whether the neurobiological basis of this addiction-like 
      behavioral disorder and substance-related addiction are comparable. In 
      substance-related addiction, attentional bias and cue reactivity are often 
      observed. We conducted a functional magnetic resonance study using a dot probe 
      paradigm with short-presentation (attentional bias) and long-presentation (cue 
      reactivity) trials in eight male pathological computer game players (PCGPs) and 
      nine healthy controls (HCs). Computer game-related and neutral computer-generated 
      pictures, as well as pictures from the International Affective Picture System 
      with positive and neutral valence, served as stimuli. PCGPs showed an attentional 
      bias toward both game-related and affective stimuli with positive valence. In 
      contrast, HCs showed no attentional bias effect at all. PCGPs showed stronger 
      brain responses in short-presentation trials compared with HCs in medial 
      prefrontal cortex (MPFC) and anterior cingulate gyrus and in long-presentation 
      trials in lingual gyrus. In an exploratory post hoc functional connectivity 
      analyses, for long-presentation trials, connectivity strength was higher between 
      right inferior frontal gyrus, which was associated with inhibition processing in 
      previous studies, and cue reactivity-related regions (left orbitofrontal cortex 
      and ventral striatum) in PCGPs. We observed behavioral and neural effects in 
      PCGPs, which are comparable with those found in substance-related addiction. 
      However, cue-related brain responses were depending on duration of cue 
      presentation. Together with the connectivity result, these findings suggest that 
      top-down inhibitory processes might suppress the cue reactivity-related neural 
      activity in long-presentation trials.
CI  - (c) 2012 The Authors, Addiction Biology (c) 2012 Society for the Study of Addiction.
FAU - Lorenz, Robert C
AU  - Lorenz RC
AD  - Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, 
      Germany. robert.lorenz@charite.de
FAU - Kruger, Jenny-Kathinka
AU  - Kruger JK
FAU - Neumann, Britta
AU  - Neumann B
FAU - Schott, Bjorn H
AU  - Schott BH
FAU - Kaufmann, Christian
AU  - Kaufmann C
FAU - Heinz, Andreas
AU  - Heinz A
FAU - Wustenberg, Torsten
AU  - Wustenberg T
LA  - eng
PT  - Journal Article
DEP - 20120912
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Attention/*physiology
MH  - Behavior, Addictive/*physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Cerebral Cortex/*physiopathology
MH  - *Cues
MH  - Hippocampus/physiopathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Inhibition, Psychological
MH  - Internet
MH  - Linear Models
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neuropsychological Tests
MH  - Photic Stimulation/methods
MH  - Reaction Time/physiology
MH  - Time Factors
MH  - Video Games/*psychology
MH  - Young Adult
EDAT- 2012/09/14 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/j.1369-1600.2012.00491.x [doi]
PST - ppublish
SO  - Addict Biol. 2013 Jan;18(1):134-46. doi: 10.1111/j.1369-1600.2012.00491.x. Epub 
      2012 Sep 12.