PMID- 22971899
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20131121
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 144
IP  - 1
DP  - 2012 Oct 31
TI  - Topical application of an ethanol extract prepared from Illicium verum suppresses 
      atopic dermatitis in NC/Nga mice.
PG  - 151-9
LID - S0378-8741(12)00567-3 [pii]
LID - 10.1016/j.jep.2012.08.042 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Illicium verum is a traditional herbal medicine 
      with anti-inflammatory properties used in Asia. However, its usefulness in the 
      treatment of allergic diseases remains unclear. This study evaluated the 
      anti-inflammatory and antiallergic effects of I. verum extract (IVE) in a mouse 
      model of atopic dermatitis. MATERIALS AND METHODS: We investigated the effects of 
      IVE on compound 48/80-induced histamine release, and phorbol 
      12-myristate13-acetate and calcium ionophore A23187-stimulated cytokines 
      secretion in MC/9 mast cells. Atopic dermatitis was induced in NC/Nga mice by 
      exposure to extract of house dust mite (Dermatophagoides farinae). After a 
      topical application of IVE on ear and skin lesions, we evaluated the severity of 
      skin symptoms, ear thickness, inflammatory cell infiltration, and serum levels of 
      immunoglobulin E (IgE), histamine, interleukin (IL)-6, and intercellular adhesion 
      molecule (ICAM)-1. In addition, we determined the expression of IL-4, IL-6, tumor 
      necrosis factor (TNF)-alpha, interferon (IFN)-gamma thymus- and activation-regulated 
      chemokine (TARC), regulated on activation, normal T cell expressed and secreted 
      (RANTES), ICAM-1, and vascular cell adhesion molecule (VCAM)-1 in ear tissues. 
      RESULTS: IVE inhibited secretion of histamine, IL-4, IL-6, and TNF-alpha from mast 
      cells in a dose-dependent manner. Topical application of IVE significantly 
      reduced dermatitis scores, ear thickness, and serum levels of IgE, histamine, 
      IL-6, and ICAM-1. Histopathological analysis demonstrated decreased epidermal 
      thickening and dermal infiltration by inflammatory cells. In the ear lesions, IVE 
      treatment reduced expression of IL-4, IL-6, TNF-alpha, TARC, RANTES, ICAM-1, and 
      VCAM-1, but not IFN-gamma. CONCLUSIONS: These results indicate that IVE inhibits 
      atopic dermatitis-like skin lesions by suppressing the expression of cytokines, 
      chemokines, and adhesion molecules. These results suggest that IVE may be a 
      potential therapeutic candidate for atopic dermatitis.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Sung, Yoon-Young
AU  - Sung YY
AD  - Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, 483 
      Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea.
FAU - Yang, Won-Kyung
AU  - Yang WK
FAU - Lee, A Yeong
AU  - Lee AY
FAU - Kim, Dong-Seon
AU  - Kim DS
FAU - Nho, Kyoung Jin
AU  - Nho KJ
FAU - Kim, Young Sang
AU  - Kim YS
FAU - Kim, Ho Kyoung
AU  - Kim HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120903
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Allergens)
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (ICAM-4 protein, mouse)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3K9958V90M (Ethanol)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Administration, Topical
MH  - Allergens/immunology
MH  - Animals
MH  - Anti-Allergic Agents/pharmacology/*therapeutic use
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Cell Adhesion Molecules/immunology
MH  - Cytokines/blood/immunology
MH  - Dermatitis, Atopic/*drug therapy/pathology
MH  - Dermatophagoides farinae/immunology
MH  - Ethanol/chemistry
MH  - Fruit
MH  - Histamine/blood
MH  - *Illicium
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mice
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Solvents/chemistry
MH  - Vascular Cell Adhesion Molecule-1/immunology
EDAT- 2012/09/14 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/08/24 00:00 [revised]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - S0378-8741(12)00567-3 [pii]
AID - 10.1016/j.jep.2012.08.042 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2012 Oct 31;144(1):151-9. doi: 10.1016/j.jep.2012.08.042. Epub 
      2012 Sep 3.