PMID- 22972240
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20181202
IS  - 1439-3964 (Electronic)
IS  - 0172-4622 (Linking)
VI  - 34
IP  - 3
DP  - 2013 Mar
TI  - The effects of aerobic training and age on plasma sICAM-1.
PG  - 253-7
LID - 10.1055/s-0032-1316317 [doi]
AB  - Chronic low-grade systemic inflammation plays a role in the development of 
      cardiovascular (CV) disease. Habitual endurance exercise training reduces the 
      risk of CV disease in part through anti-inflammatory mechanisms. The purpose of 
      this study was to investigate the effects of age, endurance training status, and 
      their interaction on pro-inflammatory plasma cytokines involved in the 
      pathogenesis of CV disease. Subjects were BMI-matched young (25+/-3 years; 
      endurance trained: n=9, sedentary: n=11) and older (62+/-5 years; 
      endurance-trained: n=12, sedentary: n=11) men. Plasma cytokine concentrations 
      were determined by multiplex cytometric bead assay. Soluble intercellular 
      adhesion molecule-1 (sICAM-1) levels were 40% higher in sedentary older men 
      compared to young sedentary subjects (P=0.048), but they were not different 
      between the young and older trained men. Furthermore, sICAM-1 levels were 
      negatively correlated with maximal oxygen uptake (V O2max; r= - 0.38, P=0.01) 
      across all subjects. There were no significant differences among the groups in 
      plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), soluble 
      tumor necrosis-alpha receptor (sTNFR), soluble CD40 ligand (sCD40L), or resistin. We 
      conclude that habitual endurance training is associated with an attenuated 
      age-related increase in plasma sICAM-1.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Many, G M
AU  - Many GM
AD  - Children's National Medical Center, Research Center for Genetic Medicine, 
      Washington DC, USA. gmany@cnmcresearch.org
FAU - Jenkins, N T
AU  - Jenkins NT
FAU - Witkowski, S
AU  - Witkowski S
FAU - Damsker, J M
AU  - Damsker JM
FAU - Hagberg, J
AU  - Hagberg J
LA  - eng
PT  - Journal Article
DEP - 20120912
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Cytokines/blood
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Sedentary Behavior
EDAT- 2012/09/14 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - 10.1055/s-0032-1316317 [doi]
PST - ppublish
SO  - Int J Sports Med. 2013 Mar;34(3):253-7. doi: 10.1055/s-0032-1316317. Epub 2012 
      Sep 12.