PMID- 22972688
OWN - NLM
STAT- MEDLINE
DCOM- 20140606
LR  - 20130930
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 35
IP  - 10
DP  - 2013 Oct
TI  - Case of pediatric acute promyelocytic leukemia presenting as extramedullary tumor 
      of the mandible.
PG  - E310-3
LID - 10.1002/hed.23163 [doi]
AB  - BACKGROUND: Acute promyelocytic leukemia (APL) is a malignant subtype of acute 
      myeloid leukemia caused by the PML-retinoic acid receptor (RAR)alpha fusion gene. APL 
      may be discovered in adulthood and diagnosed after spontaneous gingival bleeding 
      or difficulty in hemostasis after oral surgery such as tooth extraction. However, 
      APL is extremely rare in children. METHODS AND RESULTS: A 1-year-old boy 
      presented with a mass on the mentum of the mandible. The marked periosteal 
      reaction was seen on CT and MRI, leading to strong suspicion of a malignant 
      bone-derived tumor such as a sarcoma. Chromosome banding by fluorescence in situ 
      hybridization (FISH) showed PML-RARalpha, confirming the diagnosis of APL. Treatment 
      with tretinoin was immediately initiated. No signs of recurrence have been noted 
      1 year after treatment. CONCLUSIONS: We report herein a rare case involving an 
      infant with APL who presented with an extramedullary tumor of the mandible, whom 
      we treated with good results.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Yamashita, Yoshio
AU  - Yamashita Y
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saga 
      University, Saga, Japan.
FAU - Isomura, Naoko
AU  - Isomura N
FAU - Hamasaki, Yuhei
AU  - Hamasaki Y
FAU - Goto, Masaaki
AU  - Goto M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120913
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Anthracyclines)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Anthracyclines/administration & dosage
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
MH  - Biopsy, Needle
MH  - Diagnosis, Differential
MH  - Flow Cytometry
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Leukemia, Promyelocytic, Acute/diagnosis/*drug therapy/*pathology
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Mandibular Neoplasms/diagnosis/drug therapy/*pathology
MH  - Photomicrography
MH  - Rare Diseases
MH  - Risk Assessment
MH  - Sarcoma, Myeloid/diagnosis/drug therapy/*pathology
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Tretinoin/administration & dosage
OTO - NOTNLM
OT  - acute promyelocytic leukemia
OT  - granulocytic sarcoma
OT  - induction chemotherapy
OT  - infancy
OT  - mandible
EDAT- 2012/09/14 06:00
MHDA- 2014/06/07 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2014/06/07 06:00 [medline]
AID - 10.1002/hed.23163 [doi]
PST - ppublish
SO  - Head Neck. 2013 Oct;35(10):E310-3. doi: 10.1002/hed.23163. Epub 2012 Sep 13.