PMID- 22972713
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20191210
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 36
IP  - 6
DP  - 2012 Dec
TI  - Evaluation of phase-sensitive versus magnitude reconstructed inversion recovery 
      imaging for the assessment of myocardial infarction in mice with a clinical 
      magnetic resonance scanner.
PG  - 1372-82
LID - 10.1002/jmri.23789 [doi]
AB  - PURPOSE: To evaluate phase-sensitive inversion-recovery (PSIR) imaging at 1.5 T 
      in a mouse model of permanent coronary artery ligation as a potentially rapid and 
      robust alternative for the accurate assessment of myocardial infarction (MI) by 
      cardiac magnetic resonance imaging (MRI). MATERIALS AND METHODS: PSIR late 
      gadolinium enhancement (LGE) imaging was compared to conventional 2D segmented 
      inversion-recovery imaging for the assessment of murine MI. RESULTS: PSIR images 
      provided comparable contrast and kinetics of intravenously injected gadopentetate 
      dimeglumine (Gd-DTPA). At the mid-ventricular level there was good agreement 
      between conventional IR and PSIR for infarct size assessment. After intravenous 
      injection a limited time window of  approximately 6 minutes is available for delayed 
      enhancement imaging in mice. Whole-heart infarct imaging with 1 mm thick slices 
      was only possible in this restricted time frame when the PSIR method is applied, 
      avoiding the need for repetitively adapting the correct inversion time. Infarct 
      size determined by PSIR MRI demonstrated good agreement with postmortem 
      histology. Infarct size determined by PSIR LGE MRI inversely correlates with 
      left-ventricular function on day 7 after MI. CONCLUSION: The PSIR technique 
      provides stable and consistent contrast between hyperenhanced and remote 
      myocardium independent of the selected inversion time (TI) and proved to be a 
      robust, fast, and accurate tool for the assessment of MI in mice.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Wildgruber, Moritz
AU  - Wildgruber M
AD  - Department of Radiology, Klinikum Rechts der Isar, Technische Universitat 
      Munchen, Germany. moritz.wildgruber@tum.de
FAU - Settles, Marcus
AU  - Settles M
FAU - Kosanke, Katja
AU  - Kosanke K
FAU - Bielicki, Isabella
AU  - Bielicki I
FAU - Ntziachristos, Vasilis
AU  - Ntziachristos V
FAU - Rummeny, Ernst J
AU  - Rummeny EJ
FAU - Botnar, Rene M
AU  - Botnar RM
FAU - Huber, Armin M
AU  - Huber AM
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120912
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - *Algorithms
MH  - Animals
MH  - Female
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myocardial Infarction/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2012/09/14 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/01/23 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 10.1002/jmri.23789 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2012 Dec;36(6):1372-82. doi: 10.1002/jmri.23789. Epub 2012 
      Sep 12.