PMID- 22973372
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Print)
IS  - 1735-1995 (Linking)
VI  - 16
IP  - 12
DP  - 2011 Dec
TI  - Rapid exacerbation of multiple sclerosis following the initiation of 
      interferon-beta: report of nine cases.
PG  - 1619-22
AB  - BACKGROUND: Interferon-beta (IFN-beta) is an effective drug in multiple sclerosis (MS) 
      but it may cause acute exacerbation of MS following the initiation of treatment. 
      This study evaluated patients with rapid exacerbation of multiple sclerosis 
      (REMS) following the initiation of IFN-beta. METHODS: We retrospectively reviewed 
      the clinical records of 2350 patients with multiple sclerosis who started 
      treatment with IFN-beta and were registered with Isfahan MS Society (IMSS). Patients 
      with rapid exacerbation of multiple sclerosis within 24 hours after initiation of 
      IFN-beta treatment were selected and their demographic and clinical data were 
      extracted. RESULTS: We identified nine patients with rapid exacerbation of 
      multiple sclerosis following the initiation of IFN-beta. Their mean age at the time 
      of treatment with IFN-beta was 37.3 +/- 6.28 years. Seven patients had rapid 
      exacerbation of multiple sclerosis after initiation of IFN-beta 1a and two patients 
      after IFN-beta 1b. The course of disease in all of these patients was 
      relapsing-remitting. However, all had converted into secondary progression within 
      the first year after occurrence of rapid exacerbation of multiple sclerosis 
      following the initiation of IFN-beta. CONCLUSIONS: This study may indicate that the 
      effects of IFN-beta are not purely anti-inflammatory and a small percentage of MS 
      patients experience rapid exacerbation of multiple sclerosis following the 
      initiation of IFN-beta. Future studies are needed to validate our findings.
FAU - Etemadifar, Masoud
AU  - Etemadifar M
AD  - Professor, Department of Neurology, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Sarrami, Amir Hossein
AU  - Sarrami AH
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan 
      University of Medical Sciences
JID - 101235599
PMC - PMC3434905
OTO - NOTNLM
OT  - Central Nervous System
OT  - Interferon-beta
OT  - Multiple Sclerosis
OT  - Rapid Exacerbation
COIS- Conflict of Interests Authors have no conflict of interests.
EDAT- 2012/09/14 06:00
MHDA- 2012/09/14 06:01
PMCR- 2011/12/01
CRDT- 2012/09/14 06:00
PHST- 2011/09/29 00:00 [received]
PHST- 2011/12/05 00:00 [accepted]
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2012/09/14 06:01 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - JRMS-16-1619 [pii]
PST - ppublish
SO  - J Res Med Sci. 2011 Dec;16(12):1619-22.