PMID- 22974102
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20181202
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Linking)
VI  - 37 Suppl 1
DP  - 2013 Jan
TI  - The effects of alcohol abstinence on BDNF, ghrelin, and leptin secretions in 
      alcohol-dependent patients with glucose intolerance.
PG  - E52-8
LID - 10.1111/j.1530-0277.2012.01921.x [doi]
AB  - BACKGROUND: Alcohol use affecting the risk of type 2 diabetes mellitus (T2DM) is 
      poorly identified as well as the role of brain-derived neurotrophic factor 
      (BDNF), ghrelin, and leptin in alcohol dependence with T2DM. We tested the 
      hypothesis that alcohol abstinence affects diabetes-related factors and BDNF, 
      ghrelin, and leptin secretions in alcohol-dependent patients with glucose 
      intolerance. METHODS: A total of 64 male alcohol-dependent patients were 
      classified into normal glucose tolerance (NGT), pre-diabetes mellitus (pre-DM), 
      and diabetes mellitus (DM) groups according to a 75-g oral glucose tolerance test 
      (OGTT). All participants got alcohol dependence rehabilitation treatment for 30 
      days, and then we compared changes in BDNF, ghrelin, and leptin between pre- and 
      post-alcohol abstinence. RESULTS: After alcohol abstinence, both pre-DM and DM 
      groups had significantly decreased levels of fasting glucose. All 3 groups 
      exhibited elevated ghrelin levels and reduced leptin levels, but BDNF levels were 
      significantly increased only in the pre-DM group. The pre-DM group had large 
      increases in BDNF and ghrelin levels compared with those of the NGT group. 
      Moreover, decreases in homeostasis model assessment of insulin resistance 
      (HOMA-IR), fasting glucose, and leptin levels in the DM group were larger than 
      those in the NGT group. CONCLUSIONS: Alcohol abstinence might influence 
      diabetes-related factors of alcohol-dependent patients with glucose intolerance. 
      Further, BDNF, ghrelin, and leptin differently affect this improvement, depending 
      on the stage of DM. In the pre-DM group, elevated BDNF and ghrelin levels are 
      likely to influence insulin sensitivity, insulin resistance, and fasting glucose 
      levels. Further, reduced leptin levels after abstinence might be related to 
      improved glucose kinetics in patients with diabetes.
CI  - Copyright (c) 2012 by the Research Society on Alcoholism.
FAU - Kim, J H
AU  - Kim JH
AD  - Department of Biomedical Science, The Catholic University of Korea College of 
      Medicine, Seoul, South Korea.
FAU - Kim, S J
AU  - Kim SJ
FAU - Lee, W Y
AU  - Lee WY
FAU - Cheon, Y H
AU  - Cheon YH
FAU - Lee, S S
AU  - Lee SS
FAU - Ju, A
AU  - Ju A
FAU - K, Min
AU  - K M
FAU - Kim, D J
AU  - Kim DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120913
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ghrelin)
RN  - 0 (Leptin)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Alcoholism/blood/epidemiology/*metabolism
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/blood/*metabolism
MH  - Ghrelin/antagonists & inhibitors/blood/*metabolism
MH  - Glucose Intolerance/blood/epidemiology/*metabolism
MH  - Humans
MH  - Leptin/blood/*metabolism
MH  - Male
MH  - Middle Aged
MH  - *Temperance
EDAT- 2012/09/15 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/03/27 00:00 [received]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1111/j.1530-0277.2012.01921.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E52-8. doi: 
      10.1111/j.1530-0277.2012.01921.x. Epub 2012 Sep 13.