PMID- 22975845
OWN - NLM
STAT- MEDLINE
DCOM- 20130715
LR  - 20131121
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 23
IP  - 16
DP  - 2012 Nov 14
TI  - Functional roles of endogenous D-serine in pain-induced ultrasonic vocalization.
PG  - 937-41
LID - 10.1097/WNR.0b013e3283595726 [doi]
AB  - The N-methyl-D-aspartate receptor (NMDAR) is crucial for pain-related behaviors. 
      D-Serine is synthesized from L-serine by serine racemase (SR) and modulates NMDAR 
      functions by acting as an agonist at the glycine-binding site. We analyzed 
      noxious stimulus-induced ultrasonic vocalization and locomotor activity in the 
      open-field test using SR knockout (SR-KO) mice to examine the role of endogenous 
      D-serine in mammalian behaviors. SR-KO mice emitted less ultrasonic vocalization 
      after noxious stimulation (VAS) than wild-type (WT) mice. The locomotor activity 
      of WT mice decreased with repeated daily exposures to the open field, whereas 
      that of SR-KO mice remained unchanged. VAS was significantly enhanced during 
      arthritis in WT mice, whereas it was not enhanced during arthritis in SR-KO mice. 
      These results indicate that mice lacking the ability to produce D-serine 
      endogenously in the brain differ from normal mice with respect to the chronic 
      pain-induced behavioral changes.
FAU - Tsuzuki, Hitomi
AU  - Tsuzuki H
AD  - Department of Physiology and Biological Information, Dokkyo Medical University 
      School of Medicine, Mibu, Japan.
FAU - Maekawa, Masao
AU  - Maekawa M
FAU - Konno, Ryuichi
AU  - Konno R
FAU - Hori, Yuuichi
AU  - Hori Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 452VLY9402 (Serine)
SB  - IM
MH  - Animals
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity/physiology
MH  - Pain/*metabolism/pathology
MH  - Serine/*physiology
MH  - *Ultrasonics/methods
MH  - Vocalization, Animal/*physiology
EDAT- 2012/09/15 06:00
MHDA- 2013/07/17 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - 10.1097/WNR.0b013e3283595726 [doi]
PST - ppublish
SO  - Neuroreport. 2012 Nov 14;23(16):937-41. doi: 10.1097/WNR.0b013e3283595726.