PMID- 22976756
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20120914
IS  - 0016-3813 (Print)
IS  - 0016-3813 (Linking)
VI  - 148
IP  - 4
DP  - 2012 Jul-Aug
TI  - [Cells of innate and adaptive immunity in type 2 diabetes and obesity].
PG  - 381-9
AB  - Both type 2 diabetes mellitus (T2DM) and obesity are a major public health 
      problem in Mexico and around the world for increased incidence. In T2DM, insulin 
      secretion, insulin action or both are altered. Also, in T2DM as well as in 
      obesity a low grade chronic inflammation has been associated. In both conditions 
      there is an important increase of visceral adipose tissue, which induces to an 
      up-regulation of synthesis in proinflammatory molecules. This process involves 
      different subsets of the immune system. The macrophages and monocytes are the 
      best studied, but recently has been reported the involvement of other type of 
      cells; such as neutrophils, mast cells, eosinophils, dendritic cells, NKs, NKT. 
      Also, some T cells subsets, such as Th1, Th2, T regulatory, Th17 and B cells 
      seems to be involved in the low grade chronic inflammation. This review focuses 
      on recent evidences of the role of innate and adaptative immune system cells in 
      the pathology of T2DM and obesity. We concluded with the general proposal of a 
      theoretical model, how the immune cells may participate in inflammation of fat 
      tissue, insulin resistance and T2DM.
FAU - Guzman-Flores, Juan Manuel
AU  - Guzman-Flores JM
AD  - Departamento de Ciencias Medicas, Universidad de Guanajuato, Mexico.
FAU - Lopez-Briones, Sergio
AU  - Lopez-Briones S
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Celulas de la inmunidad innata y adaptativa en la diabetes mellitus tipo 2 y 
      obesidad.
PL  - Mexico
TA  - Gac Med Mex
JT  - Gaceta medica de Mexico
JID - 0010333
SB  - IM
MH  - *Adaptive Immunity
MH  - Diabetes Mellitus, Type 2/*immunology
MH  - Humans
MH  - *Immunity, Cellular
MH  - *Immunity, Innate
MH  - Inflammation/immunology
MH  - Insulin Resistance/immunology
MH  - Obesity/*immunology
EDAT- 2012/09/15 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - Gac Med Mex. 2012 Jul-Aug;148(4):381-9.