PMID- 22977478
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan
TI  - Phase I clinical study of a personalized peptide vaccination available for six 
      different human leukocyte antigen (HLA-A2, -A3, -A11, -A24, -A31 and 
      -A33)-positive patients with advanced cancer.
PG  - 109-117
AB  - The majority of peptide-based cancer vaccines under development are for human 
      leukocyte antigen (HLA)-A2- or -A24-positive patients. To overcome this 
      limitation, we conducted a phase I clinical study of peptide vaccines designed 
      for cancer patients with six different HLA-A types. Eligible patients were 
      required to have failed prior standard cancer therapies and to be positive for 
      the HLA-A2, -A24 or -A3 (A3, A11, A31 and A33) supertype. Three sets of 8 
      candidate peptides (24 peptides in total) were provided for vaccination to 
      HLA-A2(+), HLA-A24(+) and HLA-A3(+) patients, respectively. Personalization of 
      the vaccination peptides from the candidate pool was made by considering the 
      patients' HLA types and pre-existing levels of IgGs to the candidate peptides. 
      Seventeen patients were enrolled in this study. The peptide vaccinations were 
      well tolerated in all patients with no vaccine-related severe adverse events. 
      Augmentation of cytotoxic T lymphocyte (CTL) or IgG responses specific to the 
      vaccinated peptides was observed in 11 or 10 out of 13 cases tested, 
      respectively. This new type of vaccine is recommended for phase II clinical trial 
      because of its tolerability and the immune responses to the vaccinated peptides.
FAU - Yamada, Akira
AU  - Yamada A
AD  - Divisions of Cancer Vaccine Development, and.
FAU - Noguchi, Masanori
AU  - Noguchi M
FAU - Komatsu, Nobukazu
AU  - Komatsu N
FAU - Suekane, Shigetaka
AU  - Suekane S
FAU - Yutani, Shigeru
AU  - Yutani S
FAU - Moriya, Fukuko
AU  - Moriya F
FAU - Mine, Takashi
AU  - Mine T
FAU - Momozono, Kosuke
AU  - Momozono K
FAU - Kawano, Koichiro
AU  - Kawano K
FAU - Itoh, Kyogo
AU  - Itoh K
LA  - eng
PT  - Journal Article
DEP - 20101202
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3440674
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
PMCR- 2010/12/02
CRDT- 2012/09/15 06:00
PHST- 2010/10/01 00:00 [received]
PHST- 2010/12/02 00:00 [accepted]
PHST- 2012/09/15 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PHST- 2010/12/02 00:00 [pmc-release]
AID - etm-02-01-0109 [pii]
AID - 10.3892/etm.2010.177 [doi]
PST - ppublish
SO  - Exp Ther Med. 2011 Jan;2(1):109-117. doi: 10.3892/etm.2010.177. Epub 2010 Dec 2.