PMID- 2297884
OWN - NLM
STAT- MEDLINE
DCOM- 19900313
LR  - 20161123
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 81
IP  - 2 Suppl
DP  - 1990 Feb
TI  - Alterations in left ventricular diastolic function in chronic ischemic heart 
      failure. Assessment by radionuclide angiography.
PG  - III71-7
AB  - Using radionuclide angiography at rest, we studied several parameters of left 
      ventricular systolic and diastolic function in 60 patients divided into three 
      groups, a control group (G1) of 15 patients and two groups of patients with 
      chronic ischemic heart disease and previous anterior wall myocardial infarction 
      but without aneurysm or dyskinetic wall motion, a second group (G2) of 23 
      patients with no history of heart failure, and a third group (G3) of 22 patients 
      in New York Heart Association (NYHA) class II or III of heart failure. Ejection 
      fraction, peak emptying, and peak filling rates, in addition to times to reach 
      peak rates, were evaluated after constructing a global time-activity curve and 
      its first time derivative. In addition, we computed the first time-derivative 
      curves for each image pixel and obtained functional images (MIN/MAX images) 
      representing the distribution of times to peak emptying or filling rates Using a 
      left ventricular region of interest, time histograms were generated, and indexes 
      of dispersion of times to peak rates, defined as the full width at half maximum 
      of the histograms, were obtained. Significant (p less than or equal to 0.01) 
      differences were observed among all groups for ejection fraction, peak emptying 
      rate, and peak filling rate. The decrease of the peak filling rate still remained 
      significant from group G1 to group G3 even after adjustment for differences in 
      ejection fraction and heart rate. Peak filling rate was linearly correlated with 
      ejection fraction in the population with ischemic heart disease (G2 + G3) (r = 
      0.68, p less than or equal to 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Bareiss, P
AU  - Bareiss P
AD  - Service de Cardiologie, Centre Hospitalier Regional et Universitaire, Hopital de 
      Hautepierre, Strasbourg, France.
FAU - Facello, A
AU  - Facello A
FAU - Constantinesco, A
AU  - Constantinesco A
FAU - Demangeat, J L
AU  - Demangeat JL
FAU - Brunot, B
AU  - Brunot B
FAU - Arbogast, R
AU  - Arbogast R
FAU - Roul, G
AU  - Roul G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Coronary Disease/*diagnostic imaging/physiopathology
MH  - Female
MH  - Heart Failure/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/*physiology
MH  - Radionuclide Angiography
MH  - Stroke Volume/physiology
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
PST - ppublish
SO  - Circulation. 1990 Feb;81(2 Suppl):III71-7.