PMID- 22980664
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20141120
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 28
IP  - 9
DP  - 2012 Sep
TI  - [Expression of MCP-1 in the patients of chronic hepatitis B complicated with 
      nonalcoholic fatty liver disease].
PG  - 975-8
AB  - AIM: To investigate the expression level of monocyte chemoattractant protein-1 
      (MCP-1) in the liver of the patients with chronic hepatitis B (CHB) complicated 
      with non-alcoholic fatty liver diseases (NAFLD). METHODS: The study enrolled 21 
      CHB with NAFLD patients and 46 CHB without NAFLD patients as the controls. 
      Real-time quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) 
      and immunohistochemistry (IHC) were applied to detect the expression of MCP-1 at 
      the mRNA and protein levels in the liver tissues, respectively. Non-parametric 
      Mann-Whitney test was used to analyze the difference between the CHB patients 
      with and without NAFLD. RESULTS: The mRNA relative expression level of MCP-1 in 
      CHB+NAFLD group was 0.034 (0.024-0.058), higher than that in the control group 
      0.016 (0.012-0.024). The immunohistochemical score was 8.7+/-2.5 in CHB+NAFLD group 
      and 6.2+/-3.5 in the control group. The difference in MCP-1 expression at the both 
      protein and mRNA levels was significant statistically between the two groups 
      (P<0.01). CONCLUSION: MCP-1 expression level in the liver is higher in CHB with 
      NAFLD patients than that in CHB without NAFLD patients.
FAU - Shen, Hong-yan
AU  - Shen HY
AD  - Department of Clinical Laboratory, Xuzhou Central Hospital, Xuzhou, China.
FAU - Deng, Yan-chao
AU  - Deng YC
FAU - Wang, Qing-mei
AU  - Wang QM
FAU - Li, Quan-shuang
AU  - Li QS
FAU - Xu, Zhan
AU  - Xu Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/analysis/genetics/*physiology
MH  - Fatty Liver/*etiology
MH  - Hepatitis B, Chronic/*complications/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver/metabolism
MH  - Non-alcoholic Fatty Liver Disease
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2012/09/18 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Sep;28(9):975-8.