PMID- 22981920
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20130520
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 23
IP  - 6
DP  - 2013 Jun
TI  - KCNIP4 as a candidate gene for personality disorders and adult ADHD.
PG  - 436-47
LID - S0924-977X(12)00214-3 [pii]
LID - 10.1016/j.euroneuro.2012.07.017 [doi]
AB  - Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder 
      in children with striking persistence into adulthood and a high co-morbidity with 
      other psychiatric disorders, including personality disorders (PD). The 4p15.31 
      region was shown to be associated with ADHD in several genome wide association 
      studies (GWAS). In the present study we also report association of the 4p15.31 
      locus with Cluster B and Cluster C PD as identified by a pooled genome-wide 
      association study in 400 individuals suffering from PD. The gene coding for the 
      Kv channel-interacting protein 4 (KCNIP4) is located in this region. KCNIP4 is an 
      interaction partner of presenilin and plays a role in a negative feedback loop in 
      the Wnt/beta-catenin pathway. Thus, we reasoned it to be a promising candidate gene 
      for ADHD as well as for PD. To clarify the role of KCNIP4 in those disorders, we 
      conducted candidate gene based association studies in 594 patients suffering from 
      adult ADHD and 630 PD patients as compared to 974 healthy control individuals. In 
      the adult ADHD sample, six single markers and one haplotype block revealed to be 
      associated with disease (p values from 0.0079 to 0.049). Seven markers within the 
      KCNIP4 gene showed an association with PD (p values from 0.0043 to 0.0437). The 
      results of these studies suggest a role of KCNIP4 in the etiology of ADHD, PD and 
      other co-morbid disorders.
CI  - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved.
FAU - Weissflog, Lena
AU  - Weissflog L
AD  - Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry 
      Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, 
      University of Wuerzburg, Wuerzburg, Germany. Weissflog_l@klinik.uni-wuerzburg.de
FAU - Scholz, Claus-Jurgen
AU  - Scholz CJ
FAU - Jacob, Christian P
AU  - Jacob CP
FAU - Nguyen, Thuy Trang
AU  - Nguyen TT
FAU - Zamzow, Karin
AU  - Zamzow K
FAU - Gross-Lesch, Silke
AU  - Gross-Lesch S
FAU - Renner, Tobias J
AU  - Renner TJ
FAU - Romanos, Marcel
AU  - Romanos M
FAU - Rujescu, Dan
AU  - Rujescu D
FAU - Walitza, Susanne
AU  - Walitza S
FAU - Kneitz, Susanne
AU  - Kneitz S
FAU - Lesch, Klaus-Peter
AU  - Lesch KP
FAU - Reif, Andreas
AU  - Reif A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120914
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (KCNIP4 protein, human)
RN  - 0 (Kv Channel-Interacting Proteins)
SB  - IM
MH  - Adult
MH  - Attention Deficit Disorder with Hyperactivity/*genetics/metabolism
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Genetic Loci
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Germany
MH  - Humans
MH  - Kv Channel-Interacting Proteins/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Personality Disorders/*genetics/metabolism
MH  - *Polymorphism, Single Nucleotide
EDAT- 2012/09/18 06:00
MHDA- 2013/12/24 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/03/17 00:00 [received]
PHST- 2012/07/06 00:00 [revised]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - S0924-977X(12)00214-3 [pii]
AID - 10.1016/j.euroneuro.2012.07.017 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2013 Jun;23(6):436-47. doi: 
      10.1016/j.euroneuro.2012.07.017. Epub 2012 Sep 14.