PMID- 22982152
OWN - NLM
STAT- MEDLINE
DCOM- 20130121
LR  - 20121115
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 238
IP  - 2
DP  - 2012 Dec
TI  - BDNF: the career of a multifaceted neurotrophin in spinal cord injury.
PG  - 254-64
LID - S0014-4886(12)00350-0 [pii]
LID - 10.1016/j.expneurol.2012.09.001 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been identified as a potent promoter 
      of neurite growth, a finding that has led to an ongoing exploration of this 
      neurotrophin as a potential treatment for spinal cord injury. BDNF's many effects 
      in the nervous system make it an excellent candidate for neuroprotective 
      strategies as well as for promoting axonal regeneration, plasticity and 
      re-myelination. In addition, neuronal activity and physical exercise can modulate 
      the expression of BDNF, suggesting that non-invasive means to increase BDNF 
      levels might exist. Nonetheless, depending on the location, amount and duration 
      of BDNF delivery, this potent neurotrophin can also have adverse effects, such as 
      modulation of nociceptive pathways or contribution to spasticity. Taken together, 
      the benefits and possible risks require careful assessment when considering this 
      multifaceted neurotrophin as a treatment option for spinal cord injury.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Weishaupt, N
AU  - Weishaupt N
AD  - Centre for Neuroscience, University of Alberta, Edmonton, Canada. 
      weishaup@ualberta.ca
FAU - Blesch, A
AU  - Blesch A
FAU - Fouad, K
AU  - Fouad K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120912
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology/*therapeutic use
MH  - Gene Expression Regulation/drug effects/physiology
MH  - Humans
MH  - Neurons/drug effects/metabolism
MH  - Neuroprotective Agents/pharmacology/therapeutic use
MH  - Spinal Cord Injuries/*drug therapy/*metabolism/pathology
EDAT- 2012/09/18 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/08/30 00:00 [revised]
PHST- 2012/09/02 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S0014-4886(12)00350-0 [pii]
AID - 10.1016/j.expneurol.2012.09.001 [doi]
PST - ppublish
SO  - Exp Neurol. 2012 Dec;238(2):254-64. doi: 10.1016/j.expneurol.2012.09.001. Epub 
      2012 Sep 12.